DegronMD

Uniprot ID: Q5TAT6

Source protein: Collagen alpha-1

Source gene: COL13A1

Class: DEG_APCC_DBOX_1

Location: 218:226

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6847

ASA_SCORE: 85.7333

COIL: 0.8152

CONS_SCORE: 0.5361

DSS_SCORE: 0.3938

HELIX: 0.1417

FCONS_SCORE: 0.7891

RIG_SCORE: 0.7562

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G208A	TCGA-62-8395	LUAD	TCGA	HRECLSSMP	DEG_APCC_DBOX_1	0.0556
p.G208A	DO45368	LUAD	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.0556
p.K210N	TCGA-AA-A010	COAD	TCGA	HRECLSSMP	DEG_APCC_DBOX_1	0.2222
p.M225I	TCGA-AX-A0J1	UCEC	TCGA	HRECLSSMP	DEG_APCC_DBOX_1	0.6507
p.M225I	DO41199	UCEC	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.6507
p.S224R	TCGA-BR-8680	STAD	TCGA	HRECLSSMP	DEG_APCC_DBOX_1	0.6316
p.S224R	DO47769	STAD	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.6316
p.S223R	TCGA-BR-A4PF	STAD	TCGA	HRECLSSMP	DEG_APCC_DBOX_1	0.6316
p.S223R	DO38268	STAD	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.6316
p.P226S	TCGA-D1-A103	UCEC	TCGA	HRECLSSMP	DEG_APCC_DBOX_1	0.5641
p.P226S	DO231149	LUSC	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.5641
p.P226S	DO42312	UCEC	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.5641
p.G208E	TCGA-D3-A2JH	SKCM	TCGA	HRECLSSMP	DEG_APCC_DBOX_1	0.0556
p.G208E	TCGA-EE-A3JD	SKCM	TCGA	HRECLSSMP	DEG_APCC_DBOX_1	0.0556
p.G208E	DO47263	SKCM	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.0556
p.G208E	DO50299	SKCM	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.0556
p.G211V	DO233634	GACA	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.1389
p.V234F	DO229018	LICA	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.1111
p.P218S	DO222498	MELA	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.6752
p.A230S	DO220314	SARC	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.2222
p.E220K	DO229453	SKCA	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.591
p.P221H	DO42568	UCEC	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.7694
p.P217S	DO41331	UCEC	ICGC	HRECLSSMP	DEG_APCC_DBOX_1	0.3056
p.S210G	NCI-H838	lung	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.2222
p.P212T	DU-145	prostate	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.1667
p.Q212L	HT55	large_intestine	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.1667
p.V236L	NCI-H1155	lung	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.0556
p.P230S	SNU-C2B	large_intestine	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.2222
p.V227L	NCI-H1155	lung	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.3056
p.S216G	NCI-H838	lung	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.2778
p.S213N	NCI-H1435	lung	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.1944
p.P233S	SNU-C2B	large_intestine	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.1389
p.P233T	NCI-H727	lung	COSMIC	HRECLSSMP	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRECLSSMP

Degron related mutations and impact score

Drug responses associated with COL13A1 mutations

All proteins holding degron of HRECLSSMP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TAT6	Collagen alpha-1	DEG_APCC_DBOX_1	218:226	HRECLSSMP	APC,CDC20,FZR1	0.6847	More...