DegronMD

Uniprot ID: P41212

Source protein: Transcription factor ETV6

Source gene: ETV6

Class: DEG_APCC_DBOX_1

Location: 308:316

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9693

ASA_SCORE: 93.9889

COIL: 0.5669

CONS_SCORE: 0.5088

DSS_SCORE: 0.3342

HELIX: 0.3824

FCONS_SCORE: 1.1397

RIG_SCORE: 0.7544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H317P	TCGA-17-Z014	LUAD	TCGA	HREDLAYMN	DEG_APCC_DBOX_1	0.3056
p.D311N	TCGA-DK-A1A6	BLCA	TCGA	HREDLAYMN	DEG_APCC_DBOX_1	0.5821
p.D311N	DO472	BLCA	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	0.5821
p.R309W	TCGA-EE-A181	SKCM	TCGA	HREDLAYMN	DEG_APCC_DBOX_1	0.8634
p.R309W	DO37444	SKCM	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	0.8634
p.R309W	SIDM01174	Cervical Carcinoma	GDSC	HREDLAYMN	DEG_APCC_DBOX_1	0.8634
p.R309W	ACH-001402	Cervical Cancer	CCLE	HREDLAYMN	DEG_APCC_DBOX_1	0.8634
p.R309W	SW756	cervix	COSMIC	HREDLAYMN	DEG_APCC_DBOX_1	0.8634
p.G301W	TCGA-EE-A184	SKCM	TCGA	HREDLAYMN	DEG_APCC_DBOX_1	0.1389
p.G301W	DO47442	SKCM	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	0.1389
p.E310D	DO234321	ESAD	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	0.5647
p.E326Q	DO229540	UTCA	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	0.0556
p.M315L	SIDM00845	Burkitt's Lymphoma	GDSC	HREDLAYMN	DEG_APCC_DBOX_1	0.5999
p.Y314C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	HREDLAYMN	DEG_APCC_DBOX_1	0.7087
p.Y314C	ACH-000937	Leukemia	CCLE	HREDLAYMN	DEG_APCC_DBOX_1	0.7087
p.Y314C	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	HREDLAYMN	DEG_APCC_DBOX_1	0.7087
p.H298Q	ACH-001624	Brain Cancer	CCLE	HREDLAYMN	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41212	Transcription factor ETV6	DEG_APCC_DBOX_1	308:316	HREDLAYMN	APC,CDC20,FZR1	0.9693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons