DegronMD - P41212(ETV6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H317P	TCGA-17-Z014	LUAD	TCGA	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.3056
p.P19H	TCGA-60-2721	LUSC	TCGA	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.6583
p.P19H	TCGA-60-2721	LUSC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.7694
p.P19H	DO26447	LUSC	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.6583
p.P19H	DO26447	LUSC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.7694
p.P20S	TCGA-A2-A0CX	BRCA	TCGA	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.5641
p.P20S	TCGA-A2-A0CX	BRCA	TCGA	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.5641
p.P20S	DO2755	BRCA	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.5641
p.P20S	DO2755	BRCA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.5641
p.R14Q	TCGA-AP-A056	UCEC	TCGA	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2222
p.R14Q	TCGA-AP-A056	UCEC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.3056
p.R14Q	TCGA-GN-A263	SKCM	TCGA	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2222
p.R14Q	TCGA-GN-A263	SKCM	TCGA	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.3056
p.R14Q	DO36881	READ	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2222
p.R14Q	DO36881	READ	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.3056
p.R14Q	DO37766	SKCM	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2222
p.R14Q	DO37766	SKCM	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.3056
p.R14Q	DO43971	UCEC	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.2222
p.R14Q	DO43971	UCEC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.3056
p.A6V	TCGA-AP-A059	UCEC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation blocking phosphorylation signal	0.5278
p.A6V	DO41361	UCEC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation blocking phosphorylation signal	0.5278
p.S22C	TCGA-CJ-4638	KIRC	TCGA	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.7541
p.S22C	TCGA-CJ-4638	KIRC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.8652
p.S22C	DO20022	KIRC	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.7541
p.S22C	DO20022	KIRC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.8652
p.D311N	TCGA-DK-A1A6	BLCA	TCGA	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.5821
p.D311N	DO472	BLCA	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.5821
p.P19S	TCGA-DU-6407	LGG	TCGA	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.5641
p.P19S	TCGA-DU-6407	LGG	TCGA	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.6752
p.P19S	DO22295	LGG	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.5641
p.P19S	DO22295	LGG	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.6752
p.R309W	TCGA-EE-A181	SKCM	TCGA	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.8634
p.R309W	DO37444	SKCM	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.8634
p.R309W	SIDM01174	Cervical Carcinoma	GDSC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.8634
p.R309W	ACH-001402	Cervical Cancer	CCLE	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.8634
p.R309W	SW756	cervix	COSMIC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.8634
p.G301W	TCGA-EE-A184	SKCM	TCGA	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.1389
p.G301W	DO47442	SKCM	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.1389
p.A28T	TCGA-EO-A3AV	UCEC	TCGA	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.A28T	TCGA-EO-A3AV	UCEC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1667
p.A28T	DO52412	UCEC	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.A28T	DO52412	UCEC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1667
p.K11N	TCGA-FA-A7DS	DLBC	TCGA	TPPESPVPSY	DEG_COP1_1	18:27	Mutation substituting flanking lysine	0.25
p.K11N	TCGA-FA-A7DS	DLBC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation substituting flanking lysine	0.3333
p.K11N	DO219889	DLBC	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation substituting flanking lysine	0.25
p.K11N	DO219889	DLBC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation substituting flanking lysine	0.3333
p.P20Q	DO227709	COCA	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.5924
p.P20Q	DO227709	COCA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.5924
p.P25L	DO222864	COCA	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.7582
p.E310D	DO234321	ESAD	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.5647
p.E154D	DO223034	ESCA	ICGC	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.2222
p.E13K	DO11854	GBM	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.1944
p.E13K	DO11854	GBM	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.2778
p.A28S	DO228985	LICA	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.3056
p.A28S	DO228985	LICA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1667
p.V37M	DO228986	LICA	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.0556
p.C8F	DO229022	LICA	ICGC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation blocking phosphorylation signal	0.5
p.C8F	DO229022	LICA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation blocking phosphorylation signal	0.5833
p.S16L	DO220879	MELA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.7667
p.H171Y	DO220887	MELA	ICGC	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1667
p.D155N	DO220893	MELA	ICGC	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.25
p.D155N	SIDM00353	Other Sarcomas	GDSC	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.25
p.D155N	RKN	ovary	COSMIC	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.25
p.E326Q	DO229540	UTCA	ICGC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.0556
p.C8S	SIDM00845	Burkitt's Lymphoma	GDSC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation blocking phosphorylation signal	0.5
p.C8S	SIDM00845	Burkitt's Lymphoma	GDSC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation blocking phosphorylation signal	0.5833
p.C8S	SIDM00461	Acute Myeloid Leukemia	GDSC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation blocking phosphorylation signal	0.5
p.C8S	SIDM00461	Acute Myeloid Leukemia	GDSC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation blocking phosphorylation signal	0.5833
p.C8S	SIDM01519	Head and Neck Carcinoma	GDSC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation blocking phosphorylation signal	0.5
p.C8S	SIDM01519	Head and Neck Carcinoma	GDSC	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation blocking phosphorylation signal	0.5833
p.M315L	SIDM00845	Burkitt's Lymphoma	GDSC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.5999
p.S26T	SIDM00789	Colorectal Carcinoma	GDSC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.7116
p.S26T	SIDM00474	Ovarian Carcinoma	GDSC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.7116
p.S26T	OV-7	ovary	COSMIC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.7116
p.S26T	HCT-15	large intestine	COSMIC	TPPESPVPSY	DEG_COP1_1	18:27	Mutation altering degron motif	0.7116
p.S165Y	SIDM00217	Colorectal Carcinoma	GDSC	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.8231
p.S165Y	ACH-000999	Colon/Colorectal Cancer	CCLE	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.8231
p.S165Y	SNU-1040	large intestine	COSMIC	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.8231
p.Y314C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7087
p.Y314C	ACH-000937	Leukemia	CCLE	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7087
p.Y314C	PF-382	haematopoietic and lymphoid tissue	COSMIC	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation altering degron motif	0.7087
p.V166M	SIDM00026	Other Solid Cancers	GDSC	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.3056
p.E154Q	ACH-001415	Bladder Cancer	CCLE	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.2222
p.H298Q	ACH-001624	Brain Cancer	CCLE	HREDLAYMN	DEG_APCC_DBOX_1	308:316	Mutation rewiring degron network	0.0556
p.I10V	ACH-002046	Endometrial/Uterine Cancer	CCLE	TPPESPVPSY	DEG_COP1_1	18:27	Mutation rewiring degron network	0.1111
p.I10V	ACH-002046	Endometrial/Uterine Cancer	CCLE	ISYTPPES	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1944
p.R163M	CMK	haematopoietic and lymphoid tissue	COSMIC	VQRTPRPS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7521

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETV6

UniProt ID: P41212

Entrez ID: 2120

Protein name: Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETV6 in