DegronMD

Uniprot ID: P41212

Source protein: Transcription factor ETV6

Source gene: ETV6

Class: DEG_COP1_1

Location: 18:27

E3 ligase: COP1

DEGRON score: 0.9642

ASA_SCORE: 84.71

COIL: 0.9453

CONS_SCORE: 0.2304

DSS_SCORE: 0.5638

HELIX: 0.0269

FCONS_SCORE: 0.7502

RIG_SCORE: 0.6033

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P19H	TCGA-60-2721	LUSC	TCGA	TPPESPVPSY	DEG_COP1_1	0.6583
p.P19H	DO26447	LUSC	ICGC	TPPESPVPSY	DEG_COP1_1	0.6583
p.P20S	TCGA-A2-A0CX	BRCA	TCGA	TPPESPVPSY	DEG_COP1_1	0.5641
p.P20S	DO2755	BRCA	ICGC	TPPESPVPSY	DEG_COP1_1	0.5641
p.R14Q	TCGA-AP-A056	UCEC	TCGA	TPPESPVPSY	DEG_COP1_1	0.2222
p.R14Q	TCGA-GN-A263	SKCM	TCGA	TPPESPVPSY	DEG_COP1_1	0.2222
p.R14Q	DO36881	READ	ICGC	TPPESPVPSY	DEG_COP1_1	0.2222
p.R14Q	DO37766	SKCM	ICGC	TPPESPVPSY	DEG_COP1_1	0.2222
p.R14Q	DO43971	UCEC	ICGC	TPPESPVPSY	DEG_COP1_1	0.2222
p.S22C	TCGA-CJ-4638	KIRC	TCGA	TPPESPVPSY	DEG_COP1_1	0.7541
p.S22C	DO20022	KIRC	ICGC	TPPESPVPSY	DEG_COP1_1	0.7541
p.P19S	TCGA-DU-6407	LGG	TCGA	TPPESPVPSY	DEG_COP1_1	0.5641
p.P19S	DO22295	LGG	ICGC	TPPESPVPSY	DEG_COP1_1	0.5641
p.A28T	TCGA-EO-A3AV	UCEC	TCGA	TPPESPVPSY	DEG_COP1_1	0.3056
p.A28T	DO52412	UCEC	ICGC	TPPESPVPSY	DEG_COP1_1	0.3056
p.K11N	TCGA-FA-A7DS	DLBC	TCGA	TPPESPVPSY	DEG_COP1_1	0.25
p.K11N	DO219889	DLBC	ICGC	TPPESPVPSY	DEG_COP1_1	0.25
p.P20Q	DO227709	COCA	ICGC	TPPESPVPSY	DEG_COP1_1	0.5924
p.P25L	DO222864	COCA	ICGC	TPPESPVPSY	DEG_COP1_1	0.7582
p.E13K	DO11854	GBM	ICGC	TPPESPVPSY	DEG_COP1_1	0.1944
p.A28S	DO228985	LICA	ICGC	TPPESPVPSY	DEG_COP1_1	0.3056
p.V37M	DO228986	LICA	ICGC	TPPESPVPSY	DEG_COP1_1	0.0556
p.C8F	DO229022	LICA	ICGC	TPPESPVPSY	DEG_COP1_1	0.5
p.C8S	SIDM00845	Burkitt's Lymphoma	GDSC	TPPESPVPSY	DEG_COP1_1	0.5
p.C8S	SIDM00461	Acute Myeloid Leukemia	GDSC	TPPESPVPSY	DEG_COP1_1	0.5
p.C8S	SIDM01519	Head and Neck Carcinoma	GDSC	TPPESPVPSY	DEG_COP1_1	0.5
p.S26T	SIDM00789	Colorectal Carcinoma	GDSC	TPPESPVPSY	DEG_COP1_1	0.7116
p.S26T	SIDM00474	Ovarian Carcinoma	GDSC	TPPESPVPSY	DEG_COP1_1	0.7116
p.S26T	OV-7	ovary	COSMIC	TPPESPVPSY	DEG_COP1_1	0.7116
p.S26T	HCT-15	large_intestine	COSMIC	TPPESPVPSY	DEG_COP1_1	0.7116
p.I10V	ACH-002046	Endometrial/Uterine Cancer	CCLE	TPPESPVPSY	DEG_COP1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TPPESPVPSY

Degron related mutations and impact score

Drug responses associated with ETV6 mutations

All proteins holding degron of TPPESPVPSY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41212	Transcription factor ETV6	DEG_COP1_1	18:27	TPPESPVPSY	COP1	0.9642	More...