DegronMD

Uniprot ID: P41212

Source protein: Transcription factor ETV6

Source gene: ETV6

Class: DEG_SCF_FBW7_1

Location: 15:22

E3 ligase: FBXW7

DEGRON score: 0.7675

ASA_SCORE: 89.775

COIL: 0.8866

CONS_SCORE: 0.2536

DSS_SCORE: 0.5918

HELIX: 0.0239

FCONS_SCORE: 0.8631

RIG_SCORE: 0.6288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P19H	TCGA-60-2721	LUSC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	0.7694
p.P19H	DO26447	LUSC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.7694
p.P20S	TCGA-A2-A0CX	BRCA	TCGA	ISYTPPES	DEG_SCF_FBW7_1	0.5641
p.P20S	DO2755	BRCA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.5641
p.R14Q	TCGA-AP-A056	UCEC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	0.3056
p.R14Q	TCGA-GN-A263	SKCM	TCGA	ISYTPPES	DEG_SCF_FBW7_1	0.3056
p.R14Q	DO36881	READ	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.3056
p.R14Q	DO37766	SKCM	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.3056
p.R14Q	DO43971	UCEC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.3056
p.A6V	TCGA-AP-A059	UCEC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	0.5278
p.A6V	DO41361	UCEC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.5278
p.S22C	TCGA-CJ-4638	KIRC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	0.8652
p.S22C	DO20022	KIRC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.8652
p.P19S	TCGA-DU-6407	LGG	TCGA	ISYTPPES	DEG_SCF_FBW7_1	0.6752
p.P19S	DO22295	LGG	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.6752
p.A28T	TCGA-EO-A3AV	UCEC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	0.1667
p.A28T	DO52412	UCEC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.1667
p.K11N	TCGA-FA-A7DS	DLBC	TCGA	ISYTPPES	DEG_SCF_FBW7_1	0.3333
p.K11N	DO219889	DLBC	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.3333
p.P20Q	DO227709	COCA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.5924
p.E13K	DO11854	GBM	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.2778
p.A28S	DO228985	LICA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.1667
p.C8F	DO229022	LICA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.5833
p.S16L	DO220879	MELA	ICGC	ISYTPPES	DEG_SCF_FBW7_1	0.7667
p.C8S	SIDM00845	Burkitt's Lymphoma	GDSC	ISYTPPES	DEG_SCF_FBW7_1	0.5833
p.C8S	SIDM00461	Acute Myeloid Leukemia	GDSC	ISYTPPES	DEG_SCF_FBW7_1	0.5833
p.C8S	SIDM01519	Head and Neck Carcinoma	GDSC	ISYTPPES	DEG_SCF_FBW7_1	0.5833
p.I10V	ACH-002046	Endometrial/Uterine Cancer	CCLE	ISYTPPES	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41212	Transcription factor ETV6	DEG_SCF_FBW7_1	15:22	ISYTPPES	FBXW7	0.7675	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISYTPPES

Degron related mutations and impact score

Drug responses associated with ETV6 mutations

All proteins holding degron of ISYTPPES