DegronMD

Uniprot ID: P41212

Source protein: Transcription factor ETV6

Source gene: ETV6

Class: DEG_SCF_FBW7_1

Location: 158:165

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 68.6125

COIL: 0.8264

CONS_SCORE: 0.5113

DSS_SCORE: 0.6798

HELIX: 0.0411

FCONS_SCORE: 1.3683

RIG_SCORE: 0.6494

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S165Y	SIDM00217	Colorectal Carcinoma	GDSC	VQRTPRPS	DEG_SCF_FBW7_1	0.8231
p.S165Y	ACH-000999	Colon/Colorectal Cancer	CCLE	VQRTPRPS	DEG_SCF_FBW7_1	0.8231
p.S165Y	SNU-1040	large_intestine	COSMIC	VQRTPRPS	DEG_SCF_FBW7_1	0.8231
p.R163M	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	VQRTPRPS	DEG_SCF_FBW7_1	0.7521
p.V166M	SIDM00026	Other Solid Cancers	GDSC	VQRTPRPS	DEG_SCF_FBW7_1	0.3056
p.D155N	DO220893	MELA	ICGC	VQRTPRPS	DEG_SCF_FBW7_1	0.25
p.D155N	SIDM00353	Other Sarcomas	GDSC	VQRTPRPS	DEG_SCF_FBW7_1	0.25
p.D155N	RKN	ovary	COSMIC	VQRTPRPS	DEG_SCF_FBW7_1	0.25
p.E154D	DO223034	ESCA	ICGC	VQRTPRPS	DEG_SCF_FBW7_1	0.2222
p.E154Q	ACH-001415	Bladder Cancer	CCLE	VQRTPRPS	DEG_SCF_FBW7_1	0.2222
p.H171Y	DO220887	MELA	ICGC	VQRTPRPS	DEG_SCF_FBW7_1	0.1667

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P41212	Transcription factor ETV6	DEG_SCF_FBW7_1	158:165	VQRTPRPS	FBXW7	0.9993	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons