DegronMD

Uniprot ID: Q8WXW3

Source protein: Progesterone-induced-blocking factor 1

Source gene: PIBF1

Class: DEG_APCC_DBOX_1

Location: 681:689

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5454

ASA_SCORE: 98.9778

COIL: 0.0426

CONS_SCORE: 0.3987

DSS_SCORE: 0.2666

HELIX: 0.9567

FCONS_SCORE: 1.0181

RIG_SCORE: 0.8077

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H681N	TCGA-2W-A8YY	CESC	TCGA	HREELAAMK	DEG_APCC_DBOX_1	0.6312
p.H681N	DO223732	CESC	ICGC	HREELAAMK	DEG_APCC_DBOX_1	0.6312
p.R682C	TCGA-AP-A1DV	UCEC	TCGA	HREELAAMK	DEG_APCC_DBOX_1	0.8301
p.R682C	DO43186	UCEC	ICGC	HREELAAMK	DEG_APCC_DBOX_1	0.8301
p.L679I	TCGA-BS-A0UF	UCEC	TCGA	HREELAAMK	DEG_APCC_DBOX_1	0.2778
p.L679I	DO41488	UCEC	ICGC	HREELAAMK	DEG_APCC_DBOX_1	0.2778
p.V693I	TCGA-CK-5916	COAD	TCGA	HREELAAMK	DEG_APCC_DBOX_1	0.2222
p.V693I	DO8786	COAD	ICGC	HREELAAMK	DEG_APCC_DBOX_1	0.2222
p.H696L	TCGA-ER-A42K	SKCM	TCGA	HREELAAMK	DEG_APCC_DBOX_1	0.1389
p.H696L	DO51252	SKCM	ICGC	HREELAAMK	DEG_APCC_DBOX_1	0.1389
p.M695I	TCGA-XK-AAIW	PRAD	TCGA	HREELAAMK	DEG_APCC_DBOX_1	0.1667
p.M695I	DO51407	PRAD	ICGC	HREELAAMK	DEG_APCC_DBOX_1	0.1667
p.A672V	DO233944	GACA	ICGC	HREELAAMK	DEG_APCC_DBOX_1	0.0833
p.A686E	SIDM01460	Glioma	GDSC	HREELAAMK	DEG_APCC_DBOX_1	0.659
p.A686E	ACH-000592	Brain Cancer	CCLE	HREELAAMK	DEG_APCC_DBOX_1	0.659
p.R682H	SIDM01447	Glioblastoma	GDSC	HREELAAMK	DEG_APCC_DBOX_1	0.8244
p.H699Y	ACH-001278	Ovarian Cancer	CCLE	HREELAAMK	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXW3	Progesterone-induced-blocking factor 1	DEG_APCC_DBOX_1	681:689	HREELAAMK	APC,CDC20,FZR1	0.5454	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons