DegronMD - Q8WXW3(PIBF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H681N	TCGA-2W-A8YY	CESC	TCGA	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation altering degron motif	0.6312
p.H681N	DO223732	CESC	ICGC	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation altering degron motif	0.6312
p.R682C	TCGA-AP-A1DV	UCEC	TCGA	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation altering degron motif	0.8301
p.R682C	DO43186	UCEC	ICGC	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation altering degron motif	0.8301
p.L679I	TCGA-BS-A0UF	UCEC	TCGA	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.2778
p.L679I	DO41488	UCEC	ICGC	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.2778
p.D731N	TCGA-CK-4951	COAD	TCGA	IFTPKPT	DEG_SCF_FBW7_1	733:739	Mutation rewiring degron network	0.2778
p.D731N	DO10582	COAD	ICGC	IFTPKPT	DEG_SCF_FBW7_1	733:739	Mutation rewiring degron network	0.2778
p.V693I	TCGA-CK-5916	COAD	TCGA	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.2222
p.V693I	DO8786	COAD	ICGC	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.2222
p.H696L	TCGA-ER-A42K	SKCM	TCGA	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.1389
p.H696L	DO51252	SKCM	ICGC	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.1389
p.P726R	TCGA-G4-6628	COAD	TCGA	IFTPKPT	DEG_SCF_FBW7_1	733:739	Mutation rewiring degron network	0.1389
p.P726R	DO10132	COAD	ICGC	IFTPKPT	DEG_SCF_FBW7_1	733:739	Mutation rewiring degron network	0.1389
p.M695I	TCGA-XK-AAIW	PRAD	TCGA	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.1667
p.M695I	DO51407	PRAD	ICGC	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.1667
p.A672V	DO233944	GACA	ICGC	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.0833
p.E748V	DO228357	LICA	ICGC	IFTPKPT	DEG_SCF_FBW7_1	733:739	Mutation rewiring degron network	0.0833
p.V725L	DO229026	LICA	ICGC	IFTPKPT	DEG_SCF_FBW7_1	733:739	Mutation rewiring degron network	0.1111
p.T739A	SIDM02026	Colorectal Carcinoma	GDSC	IFTPKPT	DEG_SCF_FBW7_1	733:739	Mutation altering degron motif	0.7139
p.A686E	SIDM01460	Glioma	GDSC	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation altering degron motif	0.659
p.A686E	ACH-000592	Brain Cancer	CCLE	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation altering degron motif	0.659
p.P738S	SIDM00158	Glioblastoma	GDSC	IFTPKPT	DEG_SCF_FBW7_1	733:739	Mutation altering degron motif	0.5641
p.P738S	ACH-000623	Brain Cancer	CCLE	IFTPKPT	DEG_SCF_FBW7_1	733:739	Mutation altering degron motif	0.5641
p.R682H	SIDM01447	Glioblastoma	GDSC	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation altering degron motif	0.8244
p.H699Y	ACH-001278	Ovarian Cancer	CCLE	HREELAAMK	DEG_APCC_DBOX_1	681:689	Mutation rewiring degron network	0.0556

Kaplan plot for PIBF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIBF1

UniProt ID: Q8WXW3

Entrez ID: 10464

Protein name: Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIBF1 in