DegronMD

Uniprot ID: Q8WXW3

Source protein: Progesterone-induced-blocking factor 1

Source gene: PIBF1

Class: DEG_SCF_FBW7_1

Location: 733:739

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 77.9143

COIL: 0.8801

CONS_SCORE: 0.402

DSS_SCORE: 0.5964

HELIX: 0.0631

FCONS_SCORE: 1.252

RIG_SCORE: 0.7516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D731N	TCGA-CK-4951	COAD	TCGA	IFTPKPT	DEG_SCF_FBW7_1	0.2778
p.D731N	DO10582	COAD	ICGC	IFTPKPT	DEG_SCF_FBW7_1	0.2778
p.P726R	TCGA-G4-6628	COAD	TCGA	IFTPKPT	DEG_SCF_FBW7_1	0.1389
p.P726R	DO10132	COAD	ICGC	IFTPKPT	DEG_SCF_FBW7_1	0.1389
p.E748V	DO228357	LICA	ICGC	IFTPKPT	DEG_SCF_FBW7_1	0.0833
p.V725L	DO229026	LICA	ICGC	IFTPKPT	DEG_SCF_FBW7_1	0.1111
p.T739A	SIDM02026	Colorectal Carcinoma	GDSC	IFTPKPT	DEG_SCF_FBW7_1	0.7139
p.P738S	SIDM00158	Glioblastoma	GDSC	IFTPKPT	DEG_SCF_FBW7_1	0.5641
p.P738S	ACH-000623	Brain Cancer	CCLE	IFTPKPT	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXW3	Progesterone-induced-blocking factor 1	DEG_SCF_FBW7_1	733:739	IFTPKPT	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons