DegronMD

Uniprot ID: Q5VVM6

Source protein: Coiled-coil domain-containing protein 30

Source gene: CCDC30

Class: DEG_APCC_DBOX_1

Location: 642:650

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7482

ASA_SCORE: 88.4

COIL: 0.699

CONS_SCORE: 0.1812

DSS_SCORE: 0.3567

HELIX: 0.2753

FCONS_SCORE: 0.9968

RIG_SCORE: 0.7537

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L632I	TCGA-AG-A002	READ	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	0.0556
p.K653N	TCGA-AG-A002	READ	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	0.3611
p.K653N	TCGA-EI-6917	READ	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	0.3611
p.E657K	TCGA-D3-A8GI	SKCM	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	0.1389
p.P636H	TCGA-E6-A1LX	UCEC	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	0.1667
p.P650L	TCGA-EO-A22U	UCEC	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	0.6471
p.L646V	SIDM00049	Colorectal Carcinoma	GDSC	HRGKLASLP	DEG_APCC_DBOX_1	0.6765
p.L646V	ACH-001410	Bladder Cancer	CCLE	HRGKLASLP	DEG_APCC_DBOX_1	0.6765
p.L646V	ACH-002233	Colon/Colorectal Cancer	CCLE	HRGKLASLP	DEG_APCC_DBOX_1	0.6765
p.L646V	DIFI	large_intestine	COSMIC	HRGKLASLP	DEG_APCC_DBOX_1	0.6765
p.E659K	Mewo	skin	COSMIC	HRGKLASLP	DEG_APCC_DBOX_1	0.0833
p.Y657C	NCI-H748	lung	COSMIC	HRGKLASLP	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VVM6	Coiled-coil domain-containing protein 30	DEG_APCC_DBOX_1	642:650	HRGKLASLP	APC,CDC20,FZR1	0.7482	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons