DegronMD - Q5VVM6(CCDC30)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V203I	DO219552	LIHC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.7076
p.V203L	DO32912	PACA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.6765
p.L646V	SIDM00049	Colorectal Carcinoma	GDSC	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6765
p.L646V	ACH-001410	Bladder Cancer	CCLE	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6765
p.L646V	ACH-002233	Colon/Colorectal Cancer	CCLE	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6765
p.L646V	DIFI	large intestine	COSMIC	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6765
p.P650L	TCGA-EO-A22U	UCEC	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6471
p.I205V	DO23456	LINC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.5965
p.E201K	TCGA-YC-A89H	BLCA	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.591
p.E201K	DO51948	BLCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.591
p.E201Q	TCGA-DK-AA6W	BLCA	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.5633
p.E201Q	DO219009	BLCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.5633
p.K653N	TCGA-AG-A002	READ	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation substituting flanking lysine	0.3611
p.K653N	TCGA-EI-6917	READ	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation substituting flanking lysine	0.3611
p.Q207E	TCGA-4Z-AA86	BLCA	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.Q207E	DO218989	BLCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.R197M	DO229027	LICA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.Q207H	DO229264	THCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.L197W	EPLC-272H	lung	COSMIC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.V196L	TCGA-BA-4077	HNSC	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 41 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC30

UniProt ID: Q5VVM6

Entrez ID: 728621

Protein name: Coiled-coil domain-containing protein 30 (Prefoldin subunit 6-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC30 in