DegronMD - Q5VVM6(CCDC30)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q207E	TCGA-4Z-AA86	BLCA	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.Q207E	DO218989	BLCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.L632I	TCGA-AG-A002	READ	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.0556
p.K653N	TCGA-AG-A002	READ	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation substituting flanking lysine	0.3611
p.K653N	TCGA-EI-6917	READ	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation substituting flanking lysine	0.3611
p.V196L	TCGA-BA-4077	HNSC	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778
p.V196L	DO15647	HNSC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778
p.E657K	TCGA-D3-A8GI	SKCM	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.1389
p.E201Q	TCGA-DK-AA6W	BLCA	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.5633
p.E201Q	DO219009	BLCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.5633
p.P636H	TCGA-E6-A1LX	UCEC	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.1667
p.G216W	TCGA-EE-A3AD	SKCM	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0556
p.G216W	DO37707	SKCM	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0556
p.L188I	TCGA-EO-A22U	UCEC	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0556
p.L188I	DO43755	UCEC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0556
p.P650L	TCGA-EO-A22U	UCEC	TCGA	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6471
p.E201K	TCGA-YC-A89H	BLCA	TCGA	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.591
p.E201K	DO51948	BLCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.591
p.T212I	DO9876	COAD	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1667
p.Q214H	DO222798	COCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1111
p.Q214R	DO13863	GBM	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1111
p.D215Y	DO228974	LICA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0833
p.R197M	DO229027	LICA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.R208S	DO229058	LICA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778
p.V203I	DO219552	LIHC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.7076
p.I205V	DO23456	LINC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.5965
p.V203L	DO32912	PACA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.6765
p.L213S	DO38016	SKCM	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1389
p.Q207H	DO229264	THCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.K216T	DO43907	UCEC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0556
p.Q190K	DO43755	UCEC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1111
p.P192H	SIDM00282	Colorectal Carcinoma	GDSC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1667
p.P192H	ACH-000998	Colon/Colorectal Cancer	CCLE	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1667
p.P192H	CW-2	large intestine	COSMIC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1667
p.L646V	SIDM00049	Colorectal Carcinoma	GDSC	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6765
p.L646V	ACH-001410	Bladder Cancer	CCLE	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6765
p.L646V	ACH-002233	Colon/Colorectal Cancer	CCLE	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6765
p.L646V	DIFI	large intestine	COSMIC	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation altering degron motif	0.6765
p.E659K	Mewo	skin	COSMIC	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.0833
p.Y657C	NCI-H748	lung	COSMIC	HRGKLASLP	DEG_APCC_DBOX_1	642:650	Mutation rewiring degron network	0.1389
p.L197W	EPLC-272H	lung	COSMIC	LREELSHIN	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC30

UniProt ID: Q5VVM6

Entrez ID: 728621

Protein name: Coiled-coil domain-containing protein 30 (Prefoldin subunit 6-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CCDC30 in