DegronMD

Uniprot ID: Q5VVM6

Source protein: Coiled-coil domain-containing protein 30

Source gene: CCDC30

Class: DEG_APCC_DBOX_1

Location: 198:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5465

ASA_SCORE: 104.5333

COIL: 0.2053

CONS_SCORE: 0.5924

DSS_SCORE: 0.5497

HELIX: 0.7921

FCONS_SCORE: 1.0893

RIG_SCORE: 0.758

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q207E	TCGA-4Z-AA86	BLCA	TCGA	LREELSHIN	DEG_APCC_DBOX_1	0.3056
p.Q207E	DO218989	BLCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.3056
p.V196L	TCGA-BA-4077	HNSC	TCGA	LREELSHIN	DEG_APCC_DBOX_1	0.2778
p.V196L	DO15647	HNSC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.2778
p.E201Q	TCGA-DK-AA6W	BLCA	TCGA	LREELSHIN	DEG_APCC_DBOX_1	0.5633
p.E201Q	DO219009	BLCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.5633
p.G216W	TCGA-EE-A3AD	SKCM	TCGA	LREELSHIN	DEG_APCC_DBOX_1	0.0556
p.G216W	DO37707	SKCM	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.0556
p.L188I	TCGA-EO-A22U	UCEC	TCGA	LREELSHIN	DEG_APCC_DBOX_1	0.0556
p.L188I	DO43755	UCEC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.0556
p.E201K	TCGA-YC-A89H	BLCA	TCGA	LREELSHIN	DEG_APCC_DBOX_1	0.591
p.E201K	DO51948	BLCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.591
p.T212I	DO9876	COAD	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.1667
p.Q214H	DO222798	COCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.1111
p.Q214R	DO13863	GBM	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.1111
p.D215Y	DO228974	LICA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.0833
p.R197M	DO229027	LICA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.3056
p.R208S	DO229058	LICA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.2778
p.V203I	DO219552	LIHC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.7076
p.I205V	DO23456	LINC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.5965
p.V203L	DO32912	PACA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.6765
p.L213S	DO38016	SKCM	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.1389
p.Q207H	DO229264	THCA	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.3056
p.K216T	DO43907	UCEC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.0556
p.Q190K	DO43755	UCEC	ICGC	LREELSHIN	DEG_APCC_DBOX_1	0.1111
p.P192H	SIDM00282	Colorectal Carcinoma	GDSC	LREELSHIN	DEG_APCC_DBOX_1	0.1667
p.P192H	ACH-000998	Colon/Colorectal Cancer	CCLE	LREELSHIN	DEG_APCC_DBOX_1	0.1667
p.P192H	CW-2	large_intestine	COSMIC	LREELSHIN	DEG_APCC_DBOX_1	0.1667
p.L197W	EPLC-272H	lung	COSMIC	LREELSHIN	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LREELSHIN

Degron related mutations and impact score

Drug responses associated with CCDC30 mutations

All proteins holding degron of LREELSHIN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VVM6	Coiled-coil domain-containing protein 30	DEG_APCC_DBOX_1	198:206	LREELSHIN	APC,CDC20,FZR1	0.5465	More...