DegronMD

Uniprot ID: Q9P273

Source protein: Teneurin-3

Source gene: TENM3

Class: DEG_APCC_DBOX_1

Location: 1792:1800

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5746

ASA_SCORE: 57.9889

COIL: 0.2934

CONS_SCORE: 0.464

DSS_SCORE: 0.1212

HELIX: 0.0056

FCONS_SCORE: 1.0283

RIG_SCORE: 0.9138

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1796I	TCGA-D1-A16X	UCEC	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	0.7174
p.L1796I	DO41799	UCEC	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	0.7174
p.L1796I	SIDM00118	Colorectal Carcinoma	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	0.7174
p.L1796I	ACH-001081	Colon/Colorectal Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	0.7174
p.L1796I	HCC2998	large_intestine	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	0.7174
p.D1791N	TCGA-FI-A2D5	UCEC	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	0.3056
p.D1791N	TCGA-FW-A3R5	SKCM	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	0.3056
p.D1791N	TCGA-GM-A2DH	BRCA	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	0.3056
p.D1791N	DO3317	BRCA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	0.3056
p.D1791N	DO37406	SKCM	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	0.3056
p.D1791N	DO41331	UCEC	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	0.3056
p.R1793S	TCGA-FS-A1ZQ	SKCM	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	0.7427
p.R1793S	DO37442	SKCM	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	0.7427
p.T1803M	DO233109	GACA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	0.25
p.D1791Y	DO228976	LICA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	0.3056
p.W1810C	DO229038	LICA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	0.0556
p.R1793L	DO229045	LICA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	0.8428
p.D1790G	SIDM01016	T-Lymphoblastic Leukemia	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	0.2778
p.D1790G	ACH-000995	Leukemia	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	0.2778
p.D1790G	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	0.2778
p.A1800T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	0.6028
p.A1800T	ACH-000920	Leukemia	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	0.6028
p.A1800T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	0.6028
p.K1784M	SIDM00054	Pancreatic Carcinoma	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	0.2222
p.K1784M	ACH-001619	Gallbladder Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	0.2222
p.K1784M	ACH-002185	Pancreatic Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	0.2222
p.K1784M	PL18	pancreas	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	0.2222
p.D1802N	SIDM01619	Endometrial Carcinoma	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	0.2778
p.D1802N	ACH-000984	Endometrial/Uterine Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	0.2778
p.S1804P	ACH-000999	Colon/Colorectal Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	0.2222
p.S1804P	SNU-1040	large_intestine	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	0.2222
p.H1806N	ACH-002785	Unknown	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	0.1667
p.H1806R	ACH-002785	Unknown	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRKFLLRIA

Degron related mutations and impact score

Drug responses associated with TENM3 mutations

All proteins holding degron of HRKFLLRIA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P273	Teneurin-3	DEG_APCC_DBOX_1	1792:1800	HRKFLLRIA	APC,CDC20,FZR1	0.5746	More...