DegronMD - Q9P273(TENM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E397Q	TCGA-85-A4CL	LUSC	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1111
p.E397Q	DO45454	LUSC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1111
p.S421Y	TCGA-AP-A056	UCEC	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.0556
p.S421Y	TCGA-EO-A22X	UCEC	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.0556
p.S421Y	DO43907	UCEC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.0556
p.S421Y	DO43971	UCEC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.0556
p.L1796I	TCGA-D1-A16X	UCEC	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.7174
p.L1796I	DO41799	UCEC	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.7174
p.L1796I	SIDM00118	Colorectal Carcinoma	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.7174
p.L1796I	ACH-001081	Colon/Colorectal Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.7174
p.L1796I	HCC2998	large intestine	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.7174
p.P399L	TCGA-D3-A8GI	SKCM	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1667
p.P399L	DO50284	SKCM	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1667
p.P400S	TCGA-D3-A8GI	SKCM	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1944
p.P400S	DO50284	SKCM	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1944
p.G401R	TCGA-EO-A22S	UCEC	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.2222
p.G401R	DO225355	BRCA	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.2222
p.G401R	DO233882	GACA	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.2222
p.G401R	DO41590	UCEC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.2222
p.G401R	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.2222
p.D1791N	TCGA-FI-A2D5	UCEC	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.3056
p.D1791N	TCGA-FW-A3R5	SKCM	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.3056
p.D1791N	TCGA-GM-A2DH	BRCA	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.3056
p.D1791N	DO3317	BRCA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.3056
p.D1791N	DO37406	SKCM	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.3056
p.D1791N	DO41331	UCEC	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.3056
p.R1793S	TCGA-FS-A1ZQ	SKCM	TCGA	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.7427
p.R1793S	DO37442	SKCM	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.7427
p.T1803M	DO233109	GACA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.25
p.D1791Y	DO228976	LICA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.3056
p.W1810C	DO229038	LICA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.0556
p.R1793L	DO229045	LICA	ICGC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.8428
p.W404G	DO231862	LINC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.3056
p.D1790G	SIDM01016	T-Lymphoblastic Leukemia	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.2778
p.D1790G	ACH-000995	Leukemia	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.2778
p.D1790G	Jurkat	haematopoietic and lymphoid tissue	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.2778
p.A1800T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.6028
p.A1800T	ACH-000920	Leukemia	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.6028
p.A1800T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation altering degron motif	0.6028
p.I420L	SIDM00330	Neuroblastoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.0833
p.I410T	SIDM00648	Small Cell Lung Carcinoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation altering degron motif	0.5966
p.I410T	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation altering degron motif	0.5966
p.I410T	NCI-H1304	lung	COSMIC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation altering degron motif	0.5966
p.I410T	COR-L105	lung	COSMIC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation altering degron motif	0.5966
p.I398V	SIDM00845	Burkitt's Lymphoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1389
p.P399S	SIDM00007	Other Solid Cancers	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1667
p.P399S	ACH-001550	Skin Cancer	CCLE	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1667
p.P399S	ACH-001566	Skin Cancer	CCLE	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1667
p.P399S	MCC13	skin	COSMIC	RSQLFID	LIG_APCC_ABBAyCdc20_2	405:411	Mutation rewiring degron network	0.1667
p.K1784M	SIDM00054	Pancreatic Carcinoma	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation substituting flanking lysine	0.2222
p.K1784M	ACH-001619	Gallbladder Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation substituting flanking lysine	0.2222
p.K1784M	ACH-002185	Pancreatic Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation substituting flanking lysine	0.2222
p.K1784M	PL18	pancreas	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation substituting flanking lysine	0.2222
p.D1802N	SIDM01619	Endometrial Carcinoma	GDSC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.2778
p.D1802N	ACH-000984	Endometrial/Uterine Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.2778
p.S1804P	ACH-000999	Colon/Colorectal Cancer	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.2222
p.S1804P	SNU-1040	large intestine	COSMIC	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.2222
p.H1806N	ACH-002785	Unknown	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.1667
p.H1806R	ACH-002785	Unknown	CCLE	HRKFLLRIA	DEG_APCC_DBOX_1	1792:1800	Mutation rewiring degron network	0.1667

Kaplan plot for TENM3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TENM3

UniProt ID: Q9P273

Entrez ID: 55714

Protein name: Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TENM3 in