DegronMD

Uniprot ID: Q9P273

Source protein: Teneurin-3

Source gene: TENM3

Class: LIG_APCC_ABBAyCdc20_2

Location: 405:411

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5583

ASA_SCORE: 47.9714

COIL: 0.2556

CONS_SCORE: 0.392

DSS_SCORE: 0.125

HELIX: 0.0014

FCONS_SCORE: 0.921

RIG_SCORE: 0.9297

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E397Q	TCGA-85-A4CL	LUSC	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1111
p.E397Q	DO45454	LUSC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1111
p.S421Y	TCGA-AP-A056	UCEC	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.0556
p.S421Y	TCGA-EO-A22X	UCEC	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.0556
p.S421Y	DO43907	UCEC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.0556
p.S421Y	DO43971	UCEC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.0556
p.P399L	TCGA-D3-A8GI	SKCM	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1667
p.P399L	DO50284	SKCM	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1667
p.P400S	TCGA-D3-A8GI	SKCM	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1944
p.P400S	DO50284	SKCM	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1944
p.G401R	TCGA-EO-A22S	UCEC	TCGA	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.2222
p.G401R	DO225355	BRCA	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.2222
p.G401R	DO233882	GACA	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.2222
p.G401R	DO41590	UCEC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.2222
p.G401R	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.2222
p.W404G	DO231862	LINC	ICGC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.3056
p.I420L	SIDM00330	Neuroblastoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.0833
p.I410T	SIDM00648	Small Cell Lung Carcinoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.5966
p.I410T	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.5966
p.I410T	NCI-H1304	lung	COSMIC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.5966
p.I410T	COR-L105	lung	COSMIC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.5966
p.I398V	SIDM00845	Burkitt's Lymphoma	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1389
p.P399S	SIDM00007	Other Solid Cancers	GDSC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1667
p.P399S	ACH-001550	Skin Cancer	CCLE	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1667
p.P399S	ACH-001566	Skin Cancer	CCLE	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1667
p.P399S	MCC13	skin	COSMIC	RSQLFID	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RSQLFID

Degron related mutations and impact score

Drug responses associated with TENM3 mutations

All proteins holding degron of RSQLFID

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P273	Teneurin-3	LIG_APCC_ABBAyCdc20_2	405:411	RSQLFID	APC,CDC20,FZR1	0.5583	More...