DegronMD

Uniprot ID: Q13309

Source protein: S-phase kinase-associated protein 2

Source gene: SKP2

Class: DEG_APCC_DBOX_1

Location: 2:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9859

ASA_SCORE: 113.0556

COIL: 0.8234

CONS_SCORE: 0.3702

DSS_SCORE: 0.6416

HELIX: 0.1646

FCONS_SCORE: 0.9078

RIG_SCORE: 0.7743

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P10T	TCGA-AN-A046	BRCA	TCGA	HRKHLQEIP	DEG_APCC_DBOX_1	0.5919
p.P10T	DO1285	BRCA	ICGC	HRKHLQEIP	DEG_APCC_DBOX_1	0.5919
p.K4R	TCGA-DD-A1EK	LIHC	TCGA	HRKHLQEIP	DEG_APCC_DBOX_1	0.6126
p.K4R	DO48492	LIHC	ICGC	HRKHLQEIP	DEG_APCC_DBOX_1	0.6126
p.L12Q	TCGA-DU-7007	LGG	TCGA	HRKHLQEIP	DEG_APCC_DBOX_1	0.2778
p.L12Q	DO22400	LGG	ICGC	HRKHLQEIP	DEG_APCC_DBOX_1	0.2778
p.S10G	DO7810	COAD	ICGC	HRKHLQEIP	DEG_APCC_DBOX_1	0.6993
p.N15S	SIDM00537	Colorectal Carcinoma	GDSC	HRKHLQEIP	DEG_APCC_DBOX_1	0.1944
p.N15S	ACH-000982	Colon/Colorectal Cancer	CCLE	HRKHLQEIP	DEG_APCC_DBOX_1	0.1944
p.N15S	ACH-001345	Colon/Colorectal Cancer	CCLE	HRKHLQEIP	DEG_APCC_DBOX_1	0.1944
p.N15S	GP5d	large_intestine	COSMIC	HRKHLQEIP	DEG_APCC_DBOX_1	0.1944
p.L5F	DMS-79	lung	COSMIC	HRKHLQEIP	DEG_APCC_DBOX_1	0.6981
p.A13T	SNU-1040	large_intestine	COSMIC	HRKHLQEIP	DEG_APCC_DBOX_1	0.25
p.A6S	DMS-79	lung	COSMIC	HRKHLQEIP	DEG_APCC_DBOX_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13309	S-phase kinase-associated protein 2	DEG_APCC_DBOX_1	2:10	HRKHLQEIP	APC,CDC20,FZR1	0.9859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons