DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
HRKQLQDLS
Uniprot ID:
Q8N137
Source protein:
Centrobin
Source gene:
CNTROB
Class:
DEG_APCC_DBOX_1
Location:
481:489
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9273
ASA_SCORE:
107.6444
COIL:
0.216
CONS_SCORE:
0.6575
DSS_SCORE:
0.6208
HELIX:
0.7831
FCONS_SCORE:
1.104
RIG_SCORE:
0.6618
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R478W
TCGA-AJ-A3EM
UCEC
TCGA
HRKQLQDLS
DEG_APCC_DBOX_1
0.25
p.R478W
DO41680
UCEC
ICGC
HRKQLQDLS
DEG_APCC_DBOX_1
0.25
p.R472W
DO234325
ESAD
ICGC
HRKQLQDLS
DEG_APCC_DBOX_1
0.0833
p.A474T
DO234332
ESAD
ICGC
HRKQLQDLS
DEG_APCC_DBOX_1
0.1389
p.Q484H
DO50802
LIRI
ICGC
HRKQLQDLS
DEG_APCC_DBOX_1
0.647
p.S476F
DO222702
MELA
ICGC
HRKQLQDLS
DEG_APCC_DBOX_1
0.1944
p.R482S
DO27879
ORCA
ICGC
HRKQLQDLS
DEG_APCC_DBOX_1
0.7427
Drug responses associated with CNTROB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of HRKQLQDLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N137
Centrobin
DEG_APCC_DBOX_1
481:489
HRKQLQDLS
APC,CDC20,FZR1
0.9273
More...