DegronMD - Q8N137(CNTROB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H758R	TCGA-85-8070	LUSC	TCGA	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.0556
p.H758R	DO26581	LUSC	ICGC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.0556
p.R478W	TCGA-AJ-A3EM	UCEC	TCGA	HRKQLQDLS	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.25
p.R478W	DO41680	UCEC	ICGC	HRKQLQDLS	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.25
p.L770I	TCGA-CA-6718	COAD	TCGA	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.6063
p.L770I	DO7801	COAD	ICGC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.6063
p.H758Y	TCGA-ER-A42K	SKCM	TCGA	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.0556
p.H758Y	DO51252	SKCM	ICGC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.0556
p.R772W	DO230335	COCA	ICGC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7523
p.R772W	DO220886	MELA	ICGC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7523
p.R472W	DO234325	ESAD	ICGC	HRKQLQDLS	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.0833
p.A474T	DO234332	ESAD	ICGC	HRKQLQDLS	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.1389
p.E775V	DO233088	GACA	ICGC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7693
p.Q484H	DO50802	LIRI	ICGC	HRKQLQDLS	DEG_APCC_DBOX_1	481:489	Mutation altering degron motif	0.647
p.S476F	DO222702	MELA	ICGC	HRKQLQDLS	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.1944
p.P774S	DO222810	MELA	ICGC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.6752
p.P774S	DO222837	MELA	ICGC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.6752
p.R482S	DO27879	ORCA	ICGC	HRKQLQDLS	DEG_APCC_DBOX_1	481:489	Mutation altering degron motif	0.7427
p.P776H	DO232224	PBCA	ICGC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7694
p.R772Q	SIDM01113	Other Sarcomas	GDSC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.6218
p.R772Q	SK-UT-1	soft tissue	COSMIC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.6218
p.R772L	SIDM01045	Endometrial Carcinoma	GDSC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7316
p.R772L	ACH-000978	Endometrial/Uterine Cancer	CCLE	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7316
p.R772L	EN	endometrium	COSMIC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7316
p.P774L	SIDM01088	Endometrial Carcinoma	GDSC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7582
p.P774L	ACH-000965	Endometrial/Uterine Cancer	CCLE	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7582
p.P774L	RL95-2	endometrium	COSMIC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation altering degron motif	0.7582
p.P786S	SIDM01064	Hodgkin's Lymphoma	GDSC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.0556
p.P786S	ACH-000267	Lymphoma	CCLE	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.0556
p.P786S	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.0556
p.M766T	SIDM00217	Colorectal Carcinoma	GDSC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.2778
p.M766T	ACH-000999	Colon/Colorectal Cancer	CCLE	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.2778
p.M766T	SNU-1040	large intestine	COSMIC	SSLFRVPEP	DEG_COP1_1	768:776	Mutation rewiring degron network	0.2778

Kaplan plot for CNTROB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNTROB

UniProt ID: Q8N137

Entrez ID: 116840

Protein name: Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNTROB in