DegronMD

Uniprot ID: Q8N137

Source protein: Centrobin

Source gene: CNTROB

Class: DEG_COP1_1

Location: 768:776

E3 ligase: COP1

DEGRON score: 0.961

ASA_SCORE: 88.1667

COIL: 0.8136

CONS_SCORE: 0.363

DSS_SCORE: 0.6393

HELIX: 0.0518

FCONS_SCORE: 0.802

RIG_SCORE: 0.647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H758R	TCGA-85-8070	LUSC	TCGA	SSLFRVPEP	DEG_COP1_1	0.0556
p.H758R	DO26581	LUSC	ICGC	SSLFRVPEP	DEG_COP1_1	0.0556
p.L770I	TCGA-CA-6718	COAD	TCGA	SSLFRVPEP	DEG_COP1_1	0.6063
p.L770I	DO7801	COAD	ICGC	SSLFRVPEP	DEG_COP1_1	0.6063
p.H758Y	TCGA-ER-A42K	SKCM	TCGA	SSLFRVPEP	DEG_COP1_1	0.0556
p.H758Y	DO51252	SKCM	ICGC	SSLFRVPEP	DEG_COP1_1	0.0556
p.R772W	DO230335	COCA	ICGC	SSLFRVPEP	DEG_COP1_1	0.7523
p.R772W	DO220886	MELA	ICGC	SSLFRVPEP	DEG_COP1_1	0.7523
p.E775V	DO233088	GACA	ICGC	SSLFRVPEP	DEG_COP1_1	0.7693
p.P774S	DO222810	MELA	ICGC	SSLFRVPEP	DEG_COP1_1	0.6752
p.P774S	DO222837	MELA	ICGC	SSLFRVPEP	DEG_COP1_1	0.6752
p.P776H	DO232224	PBCA	ICGC	SSLFRVPEP	DEG_COP1_1	0.7694
p.R772Q	SIDM01113	Other Sarcomas	GDSC	SSLFRVPEP	DEG_COP1_1	0.6218
p.R772Q	SK-UT-1	soft_tissue	COSMIC	SSLFRVPEP	DEG_COP1_1	0.6218
p.R772L	SIDM01045	Endometrial Carcinoma	GDSC	SSLFRVPEP	DEG_COP1_1	0.7316
p.R772L	ACH-000978	Endometrial/Uterine Cancer	CCLE	SSLFRVPEP	DEG_COP1_1	0.7316
p.R772L	EN	endometrium	COSMIC	SSLFRVPEP	DEG_COP1_1	0.7316
p.P774L	SIDM01088	Endometrial Carcinoma	GDSC	SSLFRVPEP	DEG_COP1_1	0.7582
p.P774L	ACH-000965	Endometrial/Uterine Cancer	CCLE	SSLFRVPEP	DEG_COP1_1	0.7582
p.P774L	RL95-2	endometrium	COSMIC	SSLFRVPEP	DEG_COP1_1	0.7582
p.P786S	SIDM01064	Hodgkin's Lymphoma	GDSC	SSLFRVPEP	DEG_COP1_1	0.0556
p.P786S	ACH-000267	Lymphoma	CCLE	SSLFRVPEP	DEG_COP1_1	0.0556
p.P786S	HDLM-2	haematopoietic_and_lymphoid_tissue	COSMIC	SSLFRVPEP	DEG_COP1_1	0.0556
p.M766T	SIDM00217	Colorectal Carcinoma	GDSC	SSLFRVPEP	DEG_COP1_1	0.2778
p.M766T	ACH-000999	Colon/Colorectal Cancer	CCLE	SSLFRVPEP	DEG_COP1_1	0.2778
p.M766T	SNU-1040	large_intestine	COSMIC	SSLFRVPEP	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N137	Centrobin	DEG_COP1_1	768:776	SSLFRVPEP	COP1	0.961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSLFRVPEP

Degron related mutations and impact score

Drug responses associated with CNTROB mutations

All proteins holding degron of SSLFRVPEP