DegronMD

Uniprot ID: O75147

Source protein: Obscurin-like protein 1

Source gene: OBSL1

Class: DEG_APCC_DBOX_1

Location: 679:687

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8625

ASA_SCORE: 51.1889

COIL: 0.3924

CONS_SCORE: 0.5456

DSS_SCORE: 0.2786

HELIX: 0.0047

FCONS_SCORE: 0.9062

RIG_SCORE: 0.8205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A693T	TCGA-61-1738	OV	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	0.1667
p.V686A	TCGA-AA-A00N	COAD	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	0.6936
p.V686I	TCGA-BR-A4PE	STAD	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	0.5965
p.R669W	TCGA-BT-A42E	BLCA	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	0.0556
p.H679R	TCGA-CK-5916	COAD	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	0.7133
p.L683M	TCGA-EY-A215	UCEC	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	0.711
p.R671S	TCGA-GN-A262	SKCM	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	0.1111
p.Q674H	TCGA-Q1-A73O	CESC	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	0.1944
p.E673K	TCGA-ZF-A9RC	BLCA	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	0.1667
p.R671H	SIDM00496	Thyroid Gland Carcinoma	GDSC	HRLILHAVK	DEG_APCC_DBOX_1	0.1111
p.R671H	SIDM00160	Biliary Tract Carcinoma	GDSC	HRLILHAVK	DEG_APCC_DBOX_1	0.1111
p.R671H	SIDM01753	Gastric Carcinoma	GDSC	HRLILHAVK	DEG_APCC_DBOX_1	0.1111
p.F697L	SIDM00963	Breast Carcinoma	GDSC	HRLILHAVK	DEG_APCC_DBOX_1	0.0556
p.F697L	ACH-000927	Breast Cancer	CCLE	HRLILHAVK	DEG_APCC_DBOX_1	0.0556
p.F697L	BT-474	breast	COSMIC	HRLILHAVK	DEG_APCC_DBOX_1	0.0556
p.L694R	ACH-000299	Leukemia	CCLE	HRLILHAVK	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75147	Obscurin-like protein 1	DEG_APCC_DBOX_1	679:687	HRLILHAVK	APC,CDC20,FZR1	0.8625	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons