DegronMD - O75147(OBSL1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A693T	TCGA-61-1738	OV	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.1667
p.V686A	TCGA-AA-A00N	COAD	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation altering degron motif	0.6936
p.A1343V	TCGA-AJ-A3EL	UCEC	TCGA	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.2222
p.A1343V	TCGA-EO-A22R	UCEC	TCGA	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.2222
p.A1343V	DO41542	UCEC	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.2222
p.A1343V	DO42713	UCEC	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.2222
p.V686I	TCGA-BR-A4PE	STAD	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation altering degron motif	0.5965
p.R669W	TCGA-BT-A42E	BLCA	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.0556
p.H679R	TCGA-CK-5916	COAD	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation altering degron motif	0.7133
p.L683M	TCGA-EY-A215	UCEC	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation altering degron motif	0.711
p.R671S	TCGA-GN-A262	SKCM	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.1111
p.Q674H	TCGA-Q1-A73O	CESC	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.1944
p.E673K	TCGA-ZF-A9RC	BLCA	TCGA	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.1667
p.L1358Q	DO52450	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.25
p.E1365D	DO229010	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.0556
p.E1365D	DO229013	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.0556
p.E1365D	DO229016	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.0556
p.E1365D	DO229003	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.0556
p.E1365D	DO229005	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.0556
p.S1353R	DO229031	LICA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation altering degron motif	0.6316
p.A1340D	DO229006	LICA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.1389
p.G1354D	DO37410	SKCM	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation altering degron motif	0.7198
p.R1338K	DO37425	SKCM	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.0833
p.T1359M	DO38815	STAD	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.2222
p.Y1339H	DO42256	UCEC	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation rewiring degron network	0.1111
p.R671H	SIDM00496	Thyroid Gland Carcinoma	GDSC	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.1111
p.R671H	SIDM00160	Biliary Tract Carcinoma	GDSC	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.1111
p.R671H	SIDM01753	Gastric Carcinoma	GDSC	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.1111
p.F697L	SIDM00963	Breast Carcinoma	GDSC	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.0556
p.F697L	ACH-000927	Breast Cancer	CCLE	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.0556
p.F697L	BT-474	breast	COSMIC	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.0556
p.V1354M	SIDM00793	Burkitt's Lymphoma	GDSC	SRIFLVSVE	DEG_APCC_DBOX_1	1347:1355	Mutation altering degron motif	0.6097
p.L694R	ACH-000299	Leukemia	CCLE	HRLILHAVK	DEG_APCC_DBOX_1	679:687	Mutation rewiring degron network	0.1389
p.L1679F	ACH-000934	Breast Cancer	CCLE	PRLRLQALG	DEG_APCC_DBOX_1	1672:1680	Mutation altering degron motif	0.6981
p.R1683L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PRLRLQALG	DEG_APCC_DBOX_1	1672:1680	Mutation rewiring degron network	0.25
p.L1688V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PRLRLQALG	DEG_APCC_DBOX_1	1672:1680	Mutation rewiring degron network	0.1111

Kaplan plot for OBSL1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OBSL1

UniProt ID: O75147

Entrez ID: 23363

Protein name: Obscurin-like protein 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for OBSL1 in