DegronMD

Uniprot ID: O75147

Source protein: Obscurin-like protein 1

Source gene: OBSL1

Class: DEG_APCC_DBOX_1

Location: 1347:1355

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7991

ASA_SCORE: 54.2444

COIL: 0.0418

CONS_SCORE: 0.2751

DSS_SCORE: 0.1406

HELIX: 0.0018

FCONS_SCORE: 0.742

RIG_SCORE: 0.8676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1343V	TCGA-AJ-A3EL	UCEC	TCGA	SRIFLVSVE	DEG_APCC_DBOX_1	0.2222
p.A1343V	TCGA-EO-A22R	UCEC	TCGA	SRIFLVSVE	DEG_APCC_DBOX_1	0.2222
p.A1343V	DO41542	UCEC	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.2222
p.A1343V	DO42713	UCEC	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.2222
p.L1358Q	DO52450	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.25
p.E1365D	DO229010	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.0556
p.E1365D	DO229013	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.0556
p.E1365D	DO229016	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.0556
p.E1365D	DO229003	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.0556
p.E1365D	DO229005	COCA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.0556
p.S1353R	DO229031	LICA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.6316
p.A1340D	DO229006	LICA	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.1389
p.G1354D	DO37410	SKCM	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.7198
p.R1338K	DO37425	SKCM	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.0833
p.T1359M	DO38815	STAD	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.2222
p.Y1339H	DO42256	UCEC	ICGC	SRIFLVSVE	DEG_APCC_DBOX_1	0.1111
p.V1354M	SIDM00793	Burkitt's Lymphoma	GDSC	SRIFLVSVE	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75147	Obscurin-like protein 1	DEG_APCC_DBOX_1	1347:1355	SRIFLVSVE	APC,CDC20,FZR1	0.7991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons