DegronMD

Uniprot ID: O75147

Source protein: Obscurin-like protein 1

Source gene: OBSL1

Class: DEG_APCC_DBOX_1

Location: 1672:1680

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9072

ASA_SCORE: 72.9556

COIL: 0.3558

CONS_SCORE: 0.5587

DSS_SCORE: 0.3934

HELIX: 0.006

FCONS_SCORE: 1.29

RIG_SCORE: 0.8155

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1679F	ACH-000934	Breast Cancer	CCLE	PRLRLQALG	DEG_APCC_DBOX_1	0.6981
p.R1683L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PRLRLQALG	DEG_APCC_DBOX_1	0.25
p.L1688V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PRLRLQALG	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75147	Obscurin-like protein 1	DEG_APCC_DBOX_1	1672:1680	PRLRLQALG	APC,CDC20,FZR1	0.9072	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons