DegronMD

Uniprot ID: Q8N7X2

Source protein: Protein STPG3

Source gene: STPG3

Class: DEG_APCC_DBOX_1

Location: 307:315

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9446

ASA_SCORE: 81.1222

COIL: 0.6484

CONS_SCORE: 0.4382

DSS_SCORE: 0.5424

HELIX: 0.2184

FCONS_SCORE: 1.2555

RIG_SCORE: 0.7346

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A304V	SIDM00198	Ewing's Sarcoma	GDSC	HRPLLHALE	DEG_APCC_DBOX_1	0.25
p.A325V	SIDM00654	Small Cell Lung Carcinoma	GDSC	HRPLLHALE	DEG_APCC_DBOX_1	0.0556
p.A325V	NCI-H1048	lung	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	0.0556
p.L311R	KALS-1	central_nervous_system	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	0.8428
p.M302T	TOV-21G	ovary	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	0.1944
p.R299H	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	0.1111
p.H303D	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	0.2222
p.H303R	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7X2	Protein STPG3	DEG_APCC_DBOX_1	307:315	HRPLLHALE	APC,CDC20,FZR1	0.9446	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons