DegronMD - Q8N7X2(STPG3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A304V	SIDM00198	Ewing's Sarcoma	GDSC	HRPLLHALE	DEG_APCC_DBOX_1	307:315	Mutation rewiring degron network	0.25
p.R94C	SIDM00848	Ewing's Sarcoma	GDSC	TADLEVPSP	DEG_COP1_1	98:106	Mutation rewiring degron network	0.2222
p.R94C	A673	bone	COSMIC	TADLEVPSP	DEG_COP1_1	98:106	Mutation rewiring degron network	0.2222
p.A325V	SIDM00654	Small Cell Lung Carcinoma	GDSC	HRPLLHALE	DEG_APCC_DBOX_1	307:315	Mutation rewiring degron network	0.0556
p.A325V	NCI-H1048	lung	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	307:315	Mutation rewiring degron network	0.0556
p.P112R	SIDM01194	Hepatocellular Carcinoma	GDSC	TADLEVPSP	DEG_COP1_1	98:106	Mutation rewiring degron network	0.1667
p.P112R	SNU-449	liver	COSMIC	TADLEVPSP	DEG_COP1_1	98:106	Mutation rewiring degron network	0.1667
p.L101V	SIDM00568	Gastric Carcinoma	GDSC	TADLEVPSP	DEG_COP1_1	98:106	Mutation altering degron motif	0.5654
p.L101V	OCUM-1	stomach	COSMIC	TADLEVPSP	DEG_COP1_1	98:106	Mutation altering degron motif	0.5654
p.L311R	KALS-1	central nervous system	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	307:315	Mutation altering degron motif	0.8428
p.M302T	TOV-21G	ovary	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	307:315	Mutation rewiring degron network	0.1944
p.R299H	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	307:315	Mutation rewiring degron network	0.1111
p.H303D	KMS-11	haematopoietic and lymphoid tissue	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	307:315	Mutation rewiring degron network	0.2222
p.H303R	KMS-11	haematopoietic and lymphoid tissue	COSMIC	HRPLLHALE	DEG_APCC_DBOX_1	307:315	Mutation rewiring degron network	0.2222

Kaplan plot for STPG3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STPG3

UniProt ID: Q8N7X2

Entrez ID: 441476

Protein name: Protein STPG3 (Sperm-tail PG-rich repeat-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STPG3 in