DegronMD

Uniprot ID: B2RXH2

Source protein: Lysine-specific demethylase 4E

Source gene: KDM4E

Class: DEG_APCC_DBOX_1

Location: 335:343

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8908

ASA_SCORE: 86.5111

COIL: 0.6507

CONS_SCORE: 0.4202

DSS_SCORE: 0.2683

HELIX: 0.2878

FCONS_SCORE: 1.2811

RIG_SCORE: 0.8244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E331Q	TCGA-55-A48Y	LUAD	TCGA	HRQDLAIVE	DEG_APCC_DBOX_1	0.2222
p.E331Q	DO26160	LUAD	ICGC	HRQDLAIVE	DEG_APCC_DBOX_1	0.2222
p.L339V	TCGA-A5-A1OH	UCEC	TCGA	HRQDLAIVE	DEG_APCC_DBOX_1	0.6765
p.L339V	DO48180	UCEC	ICGC	HRQDLAIVE	DEG_APCC_DBOX_1	0.6765
p.R348K	TCGA-E6-A1LX	UCEC	TCGA	HRQDLAIVE	DEG_APCC_DBOX_1	0.1944
p.R348K	DO41020	UCEC	ICGC	HRQDLAIVE	DEG_APCC_DBOX_1	0.1944
p.V342L	DO229037	LICA	ICGC	HRQDLAIVE	DEG_APCC_DBOX_1	0.5654
p.E331D	DO229041	LICA	ICGC	HRQDLAIVE	DEG_APCC_DBOX_1	0.2222
p.A340V	ACH-000919	Gastric Cancer	CCLE	HRQDLAIVE	DEG_APCC_DBOX_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B2RXH2	Lysine-specific demethylase 4E	DEG_APCC_DBOX_1	335:343	HRQDLAIVE	APC,CDC20,FZR1	0.8908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons