DegronMD

Uniprot ID: P13497

Source protein: Bone morphogenetic protein 1

Source gene: BMP1

Class: DEG_APCC_DBOX_1

Location: 783:791

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8239

ASA_SCORE: 49.5222

COIL: 0.1403

CONS_SCORE: 0.5762

DSS_SCORE: 0.3615

HELIX: 0.0057

FCONS_SCORE: 0.9647

RIG_SCORE: 0.8179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T780S	TCGA-24-2290	OV	TCGA	HRVKLTFME	DEG_APCC_DBOX_1	0.25
p.T780S	DO30090	OV	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.25
p.R784W	TCGA-AA-3663	COAD	TCGA	HRVKLTFME	DEG_APCC_DBOX_1	0.8634
p.R784W	DO9346	COAD	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.8634
p.R784W	DO227646	COCA	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.8634
p.Q797H	TCGA-AP-A059	UCEC	TCGA	HRVKLTFME	DEG_APCC_DBOX_1	0.1667
p.Q797H	DO41361	UCEC	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.1667
p.G782R	TCGA-BK-A13B	UCEC	TCGA	HRVKLTFME	DEG_APCC_DBOX_1	0.3056
p.G782R	DO227976	COCA	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.3056
p.G782R	DO40825	UCEC	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.3056
p.S778Y	TCGA-ER-A19P	SKCM	TCGA	HRVKLTFME	DEG_APCC_DBOX_1	0.1944
p.S778Y	DO47623	SKCM	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.1944
p.R784L	TCGA-OR-A5JA	ACC	TCGA	HRVKLTFME	DEG_APCC_DBOX_1	0.8428
p.R801T	DO6269	CESC	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.0556
p.S778A	DO222798	COCA	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.1944
p.K799N	DO229027	LICA	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.1111
p.Q773E	DO45444	LUSC	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.0556
p.W791L	DO47578	SKCM	ICGC	HRVKLTFME	DEG_APCC_DBOX_1	0.7015

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13497	Bone morphogenetic protein 1	DEG_APCC_DBOX_1	783:791	HRVKLTFME	APC,CDC20,FZR1	0.8239	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons