DegronMD

Uniprot ID: P14859

Source protein: POU domain, class 2, transcription factor 1

Source gene: POU2F1

Class: DEG_SCF_FBW7_1

Location: 256:263

E3 ligase: FBXW7

DEGRON score: 0.9966

ASA_SCORE: 83.9

COIL: 0.8678

CONS_SCORE: 0.4796

DSS_SCORE: 0.6931

HELIX: 0.0954

FCONS_SCORE: 0.9947

RIG_SCORE: 0.7207

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S262L	TCGA-A5-A0G2	UCEC	TCGA	IAATPIQT	DEG_SCF_FBW7_1	0.7667
p.R273Q	DO36556	READ	ICGC	IAATPIQT	DEG_SCF_FBW7_1	0.0556
p.T259I	DO223282	UCEC	ICGC	IAATPIQT	DEG_SCF_FBW7_1	0.8189
p.L260I	SIDM02021	Esophageal Carcinoma	GDSC	IAATPIQT	DEG_SCF_FBW7_1	0.7174
p.S265N	SIDM00217	Colorectal Carcinoma	GDSC	IAATPIQT	DEG_SCF_FBW7_1	0.2778
p.S265N	SNU-1040	large_intestine	COSMIC	IAATPIQT	DEG_SCF_FBW7_1	0.2778
p.R266H	ACH-000997	Colon/Colorectal Cancer	CCLE	IAATPIQT	DEG_SCF_FBW7_1	0.25
p.R266H	ACH-001061	Colon/Colorectal Cancer	CCLE	IAATPIQT	DEG_SCF_FBW7_1	0.25
p.R266H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	IAATPIQT	DEG_SCF_FBW7_1	0.25
p.R266H	HCT-15	large_intestine	COSMIC	IAATPIQT	DEG_SCF_FBW7_1	0.25
p.Q260K	ACH-002017	Eye Cancer	CCLE	IAATPIQT	DEG_SCF_FBW7_1	0.6944
p.A272T	huH-1	liver	COSMIC	IAATPIQT	DEG_SCF_FBW7_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14859	POU domain, class 2, transcription factor 1	DEG_SCF_FBW7_1	256:263	IAATPIQT	FBXW7	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons