DegronMD - P14859(POU2F1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S262L	TCGA-A5-A0G2	UCEC	TCGA	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.7667
p.Q239H	TCGA-BF-A1Q0	SKCM	TCGA	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation rewiring degron network	0.0556
p.T282I	TCGA-DF-A2KN	UCEC	TCGA	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation rewiring degron network	0.2778
p.P249T	DO225079	BRCA	ICGC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation altering degron motif	0.7031
p.T251A	DO6590	CLLE	ICGC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation altering degron motif	0.825
p.D275Y	DO229027	LICA	ICGC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation altering degron motif	0.6214
p.R273Q	DO36556	READ	ICGC	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.0556
p.R273Q	DO36556	READ	ICGC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation rewiring degron network	0.3056
p.T259I	DO223282	UCEC	ICGC	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.8189
p.S239L	DO41235	UCEC	ICGC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation rewiring degron network	0.0556
p.L260I	SIDM02021	Esophageal Carcinoma	GDSC	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.7174
p.A244G	SIDM00099	Mesothelioma	GDSC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation rewiring degron network	0.1944
p.A244G	H2722	pleura	COSMIC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation rewiring degron network	0.1944
p.R277H	SIDM00789	Colorectal Carcinoma	GDSC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation altering degron motif	0.8244
p.R277H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation altering degron motif	0.8244
p.R277H	PF-382	haematopoietic and lymphoid tissue	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation altering degron motif	0.8244
p.R277H	HCT-15	large intestine	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation altering degron motif	0.8244
p.S265N	SIDM00217	Colorectal Carcinoma	GDSC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation rewiring degron network	0.0556
p.S265N	SIDM00217	Colorectal Carcinoma	GDSC	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.2778
p.S265N	SIDM00217	Colorectal Carcinoma	GDSC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation rewiring degron network	0.0833
p.S265N	SNU-1040	large intestine	COSMIC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation rewiring degron network	0.0556
p.S265N	SNU-1040	large intestine	COSMIC	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.2778
p.S265N	SNU-1040	large intestine	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation rewiring degron network	0.0833
p.P252H	SIDM01617	Endometrial Carcinoma	GDSC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation altering degron motif	0.7694
p.S251P	ACH-000992	Head and Neck Cancer	CCLE	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation altering degron motif	0.6752
p.P241H	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation rewiring degron network	0.1111
p.R266H	ACH-000997	Colon/Colorectal Cancer	CCLE	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.25
p.R266H	ACH-000997	Colon/Colorectal Cancer	CCLE	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation rewiring degron network	0.1111
p.R266H	ACH-001061	Colon/Colorectal Cancer	CCLE	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.25
p.R266H	ACH-001061	Colon/Colorectal Cancer	CCLE	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation rewiring degron network	0.1111
p.R266H	PF-382	haematopoietic and lymphoid tissue	COSMIC	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.25
p.R266H	PF-382	haematopoietic and lymphoid tissue	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation rewiring degron network	0.1111
p.R266H	HCT-15	large intestine	COSMIC	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.25
p.R266H	HCT-15	large intestine	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation rewiring degron network	0.1111
p.S254N	ACH-000999	Colon/Colorectal Cancer	CCLE	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation altering degron motif	0.7069
p.S254N	SNU-1040	large intestine	COSMIC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation altering degron motif	0.7069
p.Q260K	ACH-002017	Eye Cancer	CCLE	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.6944
p.L276V	MFE-296	endometrium	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation altering degron motif	0.6765
p.S242N	SNU-1040	large intestine	COSMIC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation rewiring degron network	0.1389
p.R254H	HCT-15	large intestine	COSMIC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation altering degron motif	0.7133
p.R254H	PF-382	haematopoietic and lymphoid tissue	COSMIC	PATPTRT	DEG_SCF_FBW7_1	249:255	Mutation altering degron motif	0.7133
p.A272T	huH-1	liver	COSMIC	IAATPIQT	DEG_SCF_FBW7_1	256:263	Mutation blocking ubiquitination signal	0.5278
p.A272T	huH-1	liver	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation blocking ubiquitination signal	0.7222
p.R288Q	SNU-81	large intestine	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation rewiring degron network	0.1111
p.G278E	COLO-783	skin	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	274:280	Mutation altering degron motif	0.7199

Kaplan plot for POU2F1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POU2F1

UniProt ID: P14859

Entrez ID: 5451

Protein name: POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POU2F1 in