DegronMD

Uniprot ID: P14859

Source protein: POU domain, class 2, transcription factor 1

Source gene: POU2F1

Class: DEG_SCF_FBW7_2

Location: 274:280

E3 ligase: FBXW7

DEGRON score: 0.9789

ASA_SCORE: 94.8714

COIL: 0.9259

CONS_SCORE: 0.5795

DSS_SCORE: 0.7114

HELIX: 0.0471

FCONS_SCORE: 0.9999

RIG_SCORE: 0.6619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T282I	TCGA-DF-A2KN	UCEC	TCGA	IDTPSLE	DEG_SCF_FBW7_2	0.2778
p.D275Y	DO229027	LICA	ICGC	IDTPSLE	DEG_SCF_FBW7_2	0.6214
p.R273Q	DO36556	READ	ICGC	IDTPSLE	DEG_SCF_FBW7_2	0.3056
p.R277H	SIDM00789	Colorectal Carcinoma	GDSC	IDTPSLE	DEG_SCF_FBW7_2	0.8244
p.R277H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	IDTPSLE	DEG_SCF_FBW7_2	0.8244
p.R277H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	0.8244
p.R277H	HCT-15	large_intestine	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	0.8244
p.S265N	SIDM00217	Colorectal Carcinoma	GDSC	IDTPSLE	DEG_SCF_FBW7_2	0.0833
p.S265N	SNU-1040	large_intestine	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	0.0833
p.R266H	ACH-000997	Colon/Colorectal Cancer	CCLE	IDTPSLE	DEG_SCF_FBW7_2	0.1111
p.R266H	ACH-001061	Colon/Colorectal Cancer	CCLE	IDTPSLE	DEG_SCF_FBW7_2	0.1111
p.R266H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	0.1111
p.R266H	HCT-15	large_intestine	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	0.1111
p.L276V	MFE-296	endometrium	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	0.6765
p.A272T	huH-1	liver	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	0.7222
p.R288Q	SNU-81	large_intestine	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	0.1111
p.G278E	COLO-783	skin	COSMIC	IDTPSLE	DEG_SCF_FBW7_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14859	POU domain, class 2, transcription factor 1	DEG_SCF_FBW7_2	274:280	IDTPSLE	FBXW7	0.9789	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons