DegronMD

Uniprot ID: P14859

Source protein: POU domain, class 2, transcription factor 1

Source gene: POU2F1

Class: DEG_SCF_FBW7_1

Location: 249:255

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 88.7429

COIL: 0.9404

CONS_SCORE: 0.5655

DSS_SCORE: 0.5994

HELIX: 0.0344

FCONS_SCORE: 1.221

RIG_SCORE: 0.6681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q239H	TCGA-BF-A1Q0	SKCM	TCGA	PATPTRT	DEG_SCF_FBW7_1	0.0556
p.P249T	DO225079	BRCA	ICGC	PATPTRT	DEG_SCF_FBW7_1	0.7031
p.T251A	DO6590	CLLE	ICGC	PATPTRT	DEG_SCF_FBW7_1	0.825
p.S239L	DO41235	UCEC	ICGC	PATPTRT	DEG_SCF_FBW7_1	0.0556
p.A244G	SIDM00099	Mesothelioma	GDSC	PATPTRT	DEG_SCF_FBW7_1	0.1944
p.A244G	H2722	pleura	COSMIC	PATPTRT	DEG_SCF_FBW7_1	0.1944
p.S265N	SIDM00217	Colorectal Carcinoma	GDSC	PATPTRT	DEG_SCF_FBW7_1	0.0556
p.S265N	SNU-1040	large_intestine	COSMIC	PATPTRT	DEG_SCF_FBW7_1	0.0556
p.P252H	SIDM01617	Endometrial Carcinoma	GDSC	PATPTRT	DEG_SCF_FBW7_1	0.7694
p.S251P	ACH-000992	Head and Neck Cancer	CCLE	PATPTRT	DEG_SCF_FBW7_1	0.6752
p.P241H	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATPTRT	DEG_SCF_FBW7_1	0.1111
p.S254N	ACH-000999	Colon/Colorectal Cancer	CCLE	PATPTRT	DEG_SCF_FBW7_1	0.7069
p.S254N	SNU-1040	large_intestine	COSMIC	PATPTRT	DEG_SCF_FBW7_1	0.7069
p.S242N	SNU-1040	large_intestine	COSMIC	PATPTRT	DEG_SCF_FBW7_1	0.1389
p.R254H	HCT-15	large_intestine	COSMIC	PATPTRT	DEG_SCF_FBW7_1	0.7133
p.R254H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PATPTRT	DEG_SCF_FBW7_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14859	POU domain, class 2, transcription factor 1	DEG_SCF_FBW7_1	249:255	PATPTRT	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons