DegronMD

Uniprot ID: P30305

Source protein: M-phase inducer phosphatase 2

Source gene: CDC25B

Class: DEG_ODPH_VHL_1

Location: 472:485

E3 ligase: VHL

DEGRON score: 0.7016

ASA_SCORE: 53.5857

COIL: 0.565

CONS_SCORE: 0.4502

DSS_SCORE: 0.0419

HELIX: 0.0379

FCONS_SCORE: 0.7487

RIG_SCORE: 0.8629

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E464D	TCGA-06-5416	GBM	TCGA	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.1111
p.E464D	DO10880	GBM	ICGC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.1111
p.R493C	TCGA-AX-A06F	UCEC	TCGA	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.1111
p.R493C	SIDM01307	Colorectal Carcinoma	GDSC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.1111
p.F489L	TCGA-B5-A11N	UCEC	TCGA	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.2222
p.F489L	DO41458	UCEC	ICGC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.2222
p.A463V	TCGA-EB-A3XB	SKCM	TCGA	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.0833
p.A463V	DO37856	SKCM	ICGC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.0833
p.P467H	DO3007	BRCA	ICGC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.1944
p.T492I	DO222596	COCA	ICGC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.1389
p.E464Q	DO48256	ESCA	ICGC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.1111
p.C473F	DO229031	LICA	ICGC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.7108
p.D462N	SIDM02038	Colorectal Carcinoma	GDSC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.0556
p.A473V	SIDM00773	Non-Cancerous	GDSC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.6936
p.A473V	SIDM00774	Breast Carcinoma	GDSC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.6936
p.V481I	SIDM00845	Burkitt's Lymphoma	GDSC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.5965
p.K479R	SIDM01162	Kidney Carcinoma	GDSC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.6126
p.K479R	ACH-001398	Kidney Cancer	CCLE	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.6126
p.K479R	SW156	kidney	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.6126
p.E488K	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.25
p.E488K	ACH-002253	Lymphoma	CCLE	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.25
p.E488K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.25
p.Q489R	OSC-20	upper_aerodigestive_tract	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.2222
p.Q489R	EN	endometrium	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.2222
p.Q489R	SNU-475	liver	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.2222
p.Q489R	MKN45	stomach	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.2222
p.Q489R	TC-YIK	cervix	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.2222
p.K465R	SW156	kidney	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.5833
p.C473Y	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.7087
p.N468S	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.2222
p.E474K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.7022
p.R479P	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.7512
p.P475L	HCC-78	lung	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.7582
p.R482H	SNU-81	large_intestine	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.8244
p.N495S	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	IAPCSLDKRVILIF	DEG_ODPH_VHL_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPCSLDKRVILIF

Degron related mutations and impact score

Drug responses associated with CDC25B mutations

All proteins holding degron of IAPCSLDKRVILIF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30305	M-phase inducer phosphatase 2	DEG_ODPH_VHL_1	472:485	IAPCSLDKRVILIF	VHL	0.7016	More...