DegronMD

Uniprot ID: Q9H7F4

Source protein: Transmembrane protein 185B

Source gene: TMEM185B

Class: DEG_ODPH_VHL_1

Location: 318:330

E3 ligase: VHL

DEGRON score: 0.8759

ASA_SCORE: 85.4308

COIL: 0.6332

CONS_SCORE: 0.3511

DSS_SCORE: 0.3996

HELIX: 0.0545

FCONS_SCORE: 0.9262

RIG_SCORE: 0.7689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P320T	TCGA-FI-A2D5	UCEC	TCGA	IAPIFGKKARVVI	DEG_ODPH_VHL_1	0.7031
p.P320T	DO41331	UCEC	ICGC	IAPIFGKKARVVI	DEG_ODPH_VHL_1	0.7031
p.V338I	DO42673	UCEC	ICGC	IAPIFGKKARVVI	DEG_ODPH_VHL_1	0.1111
p.P339S	ACH-000962	Ovarian Cancer	CCLE	IAPIFGKKARVVI	DEG_ODPH_VHL_1	0.0833
p.P339S	ACH-001145	Ovarian Cancer	CCLE	IAPIFGKKARVVI	DEG_ODPH_VHL_1	0.0833
p.A326V	ACH-002785	Unknown	CCLE	IAPIFGKKARVVI	DEG_ODPH_VHL_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7F4	Transmembrane protein 185B	DEG_ODPH_VHL_1	318:330	IAPIFGKKARVVI	VHL	0.8759	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons