DegronMD

Uniprot ID: O15405

Source protein: TOX high mobility group box family member 3

Source gene: TOX3

Class: DEG_ODPH_VHL_1

Location: 383:394

E3 ligase: VHL

DEGRON score: 0.6948

ASA_SCORE: 105.875

COIL: 0.9059

CONS_SCORE: 0.3744

DSS_SCORE: 0.4219

HELIX: 0.0798

FCONS_SCORE: 0.8283

RIG_SCORE: 0.7531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P385S	TCGA-06-5416	GBM	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.6752
p.Q373E	TCGA-34-2600	LUSC	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.0556
p.I397N	TCGA-AA-3811	COAD	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.25
p.A384T	TCGA-AX-A1CE	UCEC	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.7139
p.A384T	TCGA-BR-4201	STAD	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.7139
p.R391K	TCGA-AX-A2HC	UCEC	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.6126
p.Q396H	TCGA-MV-A51V	BLCA	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.2778
p.Q396H	DO474	BLCA	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.2778
p.I392N	DO7962	COAD	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.728
p.A399V	DO230312	COCA	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.1944
p.P380S	DO10880	GBM	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.25
p.R376W	DO50750	LICA	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.1389
p.S404W	DO231016	LUSC	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.0556
p.A379T	DO38707	STAD	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.2222
p.A379T	DO42280	UCEC	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.2222
p.R386K	DO41572	UCEC	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.7237
p.N395S	SIDM00845	Burkitt's Lymphoma	GDSC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.3056
p.N395S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.3056
p.N395S	SIDM01519	Head and Neck Carcinoma	GDSC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.3056
p.N395S	ACH-000786	Lymphoma	CCLE	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.3056
p.N395S	ACH-000992	Head and Neck Cancer	CCLE	IAPKPLTMRLPM	DEG_ODPH_VHL_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15405	TOX high mobility group box family member 3	DEG_ODPH_VHL_1	383:394	IAPKPLTMRLPM	VHL	0.6948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons