DegronMD - O15405(TOX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P385S	TCGA-06-5416	GBM	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation altering degron motif	0.6752
p.Q373E	TCGA-34-2600	LUSC	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.0556
p.E65K	TCGA-AA-3510	COAD	TCGA	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.2778
p.E65K	TCGA-AN-A046	BRCA	TCGA	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.2778
p.E65K	TCGA-D3-A3ML	SKCM	TCGA	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.2778
p.E65K	TCGA-E6-A1LX	UCEC	TCGA	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.2778
p.I397N	TCGA-AA-3811	COAD	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.25
p.A384T	TCGA-AX-A1CE	UCEC	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation altering degron motif	0.7139
p.A384T	TCGA-BR-4201	STAD	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation altering degron motif	0.7139
p.R391K	TCGA-AX-A2HC	UCEC	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation altering degron motif	0.6126
p.P72S	TCGA-EK-A3GK	CESC	TCGA	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation altering degron motif	0.5641
p.P72S	DO49964	CESC	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation altering degron motif	0.5641
p.Q396H	TCGA-MV-A51V	BLCA	TCGA	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.2778
p.Q396H	DO474	BLCA	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.2778
p.E63K	TCGA-YD-A9TA	SKCM	TCGA	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.2222
p.T70M	TCGA-YZ-A985	UVM	TCGA	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation altering degron motif	0.7423
p.T70M	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation altering degron motif	0.7423
p.T70M	ACH-000150	Lung Cancer	CCLE	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation altering degron motif	0.7423
p.E60K	DO225282	BRCA	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.1389
p.E60K	DO1285	BRCA	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.1389
p.E60K	DO7783	COAD	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.1389
p.E60K	DO47413	SKCM	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.1389
p.E60K	DO41020	UCEC	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.1389
p.Q84E	DO228441	BRCA	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.0556
p.Q84E	DO230961	LUSC	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.0556
p.Q84E	DO224594	LUSC	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.0556
p.I392N	DO7962	COAD	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation altering degron motif	0.728
p.A399V	DO230312	COCA	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.1944
p.P380S	DO10880	GBM	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.25
p.P72T	DO228948	LICA	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation altering degron motif	0.5919
p.R376W	DO50750	LICA	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.1389
p.S404W	DO231016	LUSC	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.0556
p.E58K	DO219503	SKCM	ICGC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.0833
p.A379T	DO38707	STAD	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.2222
p.A379T	DO42280	UCEC	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.2222
p.R386K	DO41572	UCEC	ICGC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation altering degron motif	0.7237
p.N395S	SIDM00845	Burkitt's Lymphoma	GDSC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.3056
p.N395S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.3056
p.N395S	SIDM01519	Head and Neck Carcinoma	GDSC	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.3056
p.N395S	ACH-000786	Lymphoma	CCLE	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.3056
p.N395S	ACH-000992	Head and Neck Cancer	CCLE	IAPKPLTMRLPM	DEG_ODPH_VHL_1	383:394	Mutation rewiring degron network	0.3056
p.P67L	SIDM00652	Small Cell Lung Carcinoma	GDSC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation altering degron motif	0.6471
p.P67L	ACH-000780	Lung Cancer	CCLE	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation altering degron motif	0.6471
p.P67L	NCI-H1105	lung	COSMIC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation altering degron motif	0.6471
p.F64L	ACH-000262	Kidney Cancer	CCLE	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.25
p.P62L	NCI-H1105	lung	COSMIC	PPITPPPE	DEG_SCF_FBW7_2	67:74	Mutation rewiring degron network	0.1944

Kaplan plot for TOX3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOX3

UniProt ID: O15405

Entrez ID: 27324

Protein name: TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOX3 in