DegronMD

Uniprot ID: O15405

Source protein: TOX high mobility group box family member 3

Source gene: TOX3

Class: DEG_SCF_FBW7_2

Location: 67:74

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 74.175

COIL: 0.9763

CONS_SCORE: 0.3784

DSS_SCORE: 0.7732

HELIX: 0.0096

FCONS_SCORE: 1.1132

RIG_SCORE: 0.6309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E65K	TCGA-AA-3510	COAD	TCGA	PPITPPPE	DEG_SCF_FBW7_2	0.2778
p.E65K	TCGA-AN-A046	BRCA	TCGA	PPITPPPE	DEG_SCF_FBW7_2	0.2778
p.E65K	TCGA-D3-A3ML	SKCM	TCGA	PPITPPPE	DEG_SCF_FBW7_2	0.2778
p.E65K	TCGA-E6-A1LX	UCEC	TCGA	PPITPPPE	DEG_SCF_FBW7_2	0.2778
p.P72S	TCGA-EK-A3GK	CESC	TCGA	PPITPPPE	DEG_SCF_FBW7_2	0.5641
p.P72S	DO49964	CESC	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.5641
p.E63K	TCGA-YD-A9TA	SKCM	TCGA	PPITPPPE	DEG_SCF_FBW7_2	0.2222
p.T70M	TCGA-YZ-A985	UVM	TCGA	PPITPPPE	DEG_SCF_FBW7_2	0.7423
p.T70M	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	PPITPPPE	DEG_SCF_FBW7_2	0.7423
p.T70M	ACH-000150	Lung Cancer	CCLE	PPITPPPE	DEG_SCF_FBW7_2	0.7423
p.E60K	DO225282	BRCA	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.1389
p.E60K	DO1285	BRCA	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.1389
p.E60K	DO7783	COAD	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.1389
p.E60K	DO47413	SKCM	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.1389
p.E60K	DO41020	UCEC	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.1389
p.Q84E	DO228441	BRCA	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.0556
p.Q84E	DO230961	LUSC	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.0556
p.Q84E	DO224594	LUSC	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.0556
p.P72T	DO228948	LICA	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.5919
p.E58K	DO219503	SKCM	ICGC	PPITPPPE	DEG_SCF_FBW7_2	0.0833
p.P67L	SIDM00652	Small Cell Lung Carcinoma	GDSC	PPITPPPE	DEG_SCF_FBW7_2	0.6471
p.P67L	ACH-000780	Lung Cancer	CCLE	PPITPPPE	DEG_SCF_FBW7_2	0.6471
p.P67L	NCI-H1105	lung	COSMIC	PPITPPPE	DEG_SCF_FBW7_2	0.6471
p.F64L	ACH-000262	Kidney Cancer	CCLE	PPITPPPE	DEG_SCF_FBW7_2	0.25
p.P62L	NCI-H1105	lung	COSMIC	PPITPPPE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15405	TOX high mobility group box family member 3	DEG_SCF_FBW7_2	67:74	PPITPPPE	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons