DegronMD

Uniprot ID: O94900

Source protein: Thymocyte selection-associated high mobility group box protein TOX

Source gene: TOX

Class: DEG_ODPH_VHL_1

Location: 396:408

E3 ligase: VHL

DEGRON score: 0.9691

ASA_SCORE: 104.6385

COIL: 0.9285

CONS_SCORE: 0.2827

DSS_SCORE: 0.5547

HELIX: 0.0399

FCONS_SCORE: 0.9479

RIG_SCORE: 0.6545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H389D	TCGA-86-8358	LUAD	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.1389
p.H389D	DO25471	LUAD	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.1389
p.P390A	TCGA-96-A4JK	LUSC	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.1667
p.P390A	DO45442	LUSC	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.1667
p.M388V	TCGA-AA-3663	COAD	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.1111
p.M388V	DO9346	COAD	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.1111
p.P400L	TCGA-DF-A2KZ	UCEC	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.6471
p.P400L	DO233782	GACA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.6471
p.P400L	DO52409	UCEC	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.6471
p.R394S	TCGA-N5-A4RN	UCS	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.2778
p.A387V	DO233791	GACA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.0833
p.N402S	DO233804	GACA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.5958
p.N402K	DO228948	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.5806
p.N395K	DO229022	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.3056
p.I396M	DO229026	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.7618
p.A397D	DO229009	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.7793
p.P405T	DO50737	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.5919
p.Q403K	SIDM00199	Chondrosarcoma	GDSC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.5833
p.Q403K	ACH-002099	Bone Cancer	CCLE	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.5833
p.Q403K	CS1	bone	COSMIC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.5833
p.R394K	ACH-002396	Bone Cancer	CCLE	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.2778
p.R394K	Sarc9371	bone	COSMIC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94900	Thymocyte selection-associated high mobility group box protein TOX	DEG_ODPH_VHL_1	396:408	IAPKPNNQMPVTV	VHL	0.9691	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons