DegronMD - O94900(TOX)

FUNCTION: Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (By similarity). Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate. May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (By similarity). Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches. Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment. Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells. Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC) (By similarity). May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage. Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:21126536) (By similarity). Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming. May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (By similarity). {ECO:0000250|UniProtKB:Q66JW3, ECO:0000269|PubMed:21126536}. View more >>

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P139S	TCGA-5M-AAT6	COAD	TCGA	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.2222
p.P139S	TCGA-AA-3977	COAD	TCGA	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.2222
p.P139S	DO223703	COAD	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.2222
p.P139S	DO8730	COAD	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.2222
p.H389D	TCGA-86-8358	LUAD	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.1389
p.H389D	DO25471	LUAD	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.1389
p.P390A	TCGA-96-A4JK	LUSC	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.1667
p.P390A	DO45442	LUSC	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.1667
p.M388V	TCGA-AA-3663	COAD	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.1111
p.M388V	DO9346	COAD	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.1111
p.T147A	TCGA-AX-A063	UCEC	TCGA	NPEGTQYSSHP	CBL_PTK	143:153	Mutation altering degron motif	0.6028
p.T147A	DO42201	UCEC	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation altering degron motif	0.6028
p.M158I	TCGA-CC-A8HT	LIHC	TCGA	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.1944
p.M158I	DO222439	BTCA	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.1944
p.M158I	DO52187	LIHC	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.1944
p.M155I	TCGA-D3-A51R	SKCM	TCGA	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.2778
p.M155I	DO47480	SKCM	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.2778
p.P400L	TCGA-DF-A2KZ	UCEC	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.6471
p.P400L	DO233782	GACA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.6471
p.P400L	DO52409	UCEC	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.6471
p.S134F	TCGA-EE-A2GB	SKCM	TCGA	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.0833
p.S134F	DO222683	MELA	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.0833
p.S134F	DO37417	SKCM	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.0833
p.R142Q	TCGA-FR-A3YO	SKCM	TCGA	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.3056
p.R142Q	DO37419	SKCM	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.3056
p.R142Q	SIDM00537	Colorectal Carcinoma	GDSC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.3056
p.R394S	TCGA-N5-A4RN	UCS	TCGA	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.2778
p.A157D	DO225334	BRCA	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.2222
p.G146R	DO228473	GACA	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation altering degron motif	0.6457
p.A387V	DO233791	GACA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.0833
p.N402S	DO233804	GACA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.5958
p.N402K	DO228948	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.5806
p.P144Q	DO229018	LICA	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation altering degron motif	0.5924
p.N395K	DO229022	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.3056
p.I396M	DO229026	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.7618
p.P160Q	DO229031	LICA	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.1389
p.Q163K	DO229035	LICA	ICGC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.0556
p.A397D	DO229009	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.7793
p.P405T	DO50737	LICA	ICGC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.5919
p.R159G	SIDM00212	Glioblastoma	GDSC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.1667
p.R159G	ACH-000464	Brain Cancer	CCLE	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.1667
p.R159G	CAS-1	central nervous system	COSMIC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.1667
p.S150N	SIDM00878	Breast Carcinoma	GDSC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation altering degron motif	0.818
p.S150N	ACH-000930	Breast Cancer	CCLE	NPEGTQYSSHP	CBL_PTK	143:153	Mutation altering degron motif	0.818
p.S150N	HCC1569	breast	COSMIC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation altering degron motif	0.818
p.Q403K	SIDM00199	Chondrosarcoma	GDSC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.5833
p.Q403K	ACH-002099	Bone Cancer	CCLE	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.5833
p.Q403K	CS1	bone	COSMIC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation altering degron motif	0.5833
p.R142G	SIDM00847	Rhabdomyosarcoma	GDSC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.3056
p.R142G	ACH-000169	Sarcoma	CCLE	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.3056
p.R142G	RD	soft tissue	COSMIC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.3056
p.G162D	SIDM00217	Colorectal Carcinoma	GDSC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.0833
p.G162D	SNU-1040	large intestine	COSMIC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.0833
p.Q148H	SIDM01591	Breast Carcinoma	GDSC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation altering degron motif	0.647
p.Q148H	ACH-000540	Non-Cancerous	CCLE	NPEGTQYSSHP	CBL_PTK	143:153	Mutation altering degron motif	0.647
p.R161M	SIDM01574	Plasma Cell Myeloma	GDSC	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.1111
p.R161M	ACH-000588	Myeloma	CCLE	NPEGTQYSSHP	CBL_PTK	143:153	Mutation rewiring degron network	0.1111
p.R394K	ACH-002396	Bone Cancer	CCLE	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.2778
p.R394K	Sarc9371	bone	COSMIC	IAPKPNNQMPVTV	DEG_ODPH_VHL_1	396:408	Mutation rewiring degron network	0.2778

Kaplan plot for TOX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOX

UniProt ID: O94900

Entrez ID: 9760

Protein name: Thymocyte selection-associated high mobility group box protein TOX (Thymus high mobility group box protein TOX)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOX in