DegronMD

Uniprot ID: O94900

Source protein: Thymocyte selection-associated high mobility group box protein TOX

Source gene: TOX

Class: CBL_PTK

Location: 143:153

E3 ligase: CBL

DEGRON score: 0.889

ASA_SCORE: 72.0364

COIL: 0.8276

CONS_SCORE: 0.3852

DSS_SCORE: 0.7021

HELIX: 0.0795

FCONS_SCORE: 0.9544

RIG_SCORE: 0.6253

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P139S	TCGA-5M-AAT6	COAD	TCGA	NPEGTQYSSHP	CBL_PTK	0.2222
p.P139S	TCGA-AA-3977	COAD	TCGA	NPEGTQYSSHP	CBL_PTK	0.2222
p.P139S	DO223703	COAD	ICGC	NPEGTQYSSHP	CBL_PTK	0.2222
p.P139S	DO8730	COAD	ICGC	NPEGTQYSSHP	CBL_PTK	0.2222
p.T147A	TCGA-AX-A063	UCEC	TCGA	NPEGTQYSSHP	CBL_PTK	0.6028
p.T147A	DO42201	UCEC	ICGC	NPEGTQYSSHP	CBL_PTK	0.6028
p.M158I	TCGA-CC-A8HT	LIHC	TCGA	NPEGTQYSSHP	CBL_PTK	0.1944
p.M158I	DO222439	BTCA	ICGC	NPEGTQYSSHP	CBL_PTK	0.1944
p.M158I	DO52187	LIHC	ICGC	NPEGTQYSSHP	CBL_PTK	0.1944
p.M155I	TCGA-D3-A51R	SKCM	TCGA	NPEGTQYSSHP	CBL_PTK	0.2778
p.M155I	DO47480	SKCM	ICGC	NPEGTQYSSHP	CBL_PTK	0.2778
p.S134F	TCGA-EE-A2GB	SKCM	TCGA	NPEGTQYSSHP	CBL_PTK	0.0833
p.S134F	DO222683	MELA	ICGC	NPEGTQYSSHP	CBL_PTK	0.0833
p.S134F	DO37417	SKCM	ICGC	NPEGTQYSSHP	CBL_PTK	0.0833
p.R142Q	TCGA-FR-A3YO	SKCM	TCGA	NPEGTQYSSHP	CBL_PTK	0.3056
p.R142Q	DO37419	SKCM	ICGC	NPEGTQYSSHP	CBL_PTK	0.3056
p.R142Q	SIDM00537	Colorectal Carcinoma	GDSC	NPEGTQYSSHP	CBL_PTK	0.3056
p.A157D	DO225334	BRCA	ICGC	NPEGTQYSSHP	CBL_PTK	0.2222
p.G146R	DO228473	GACA	ICGC	NPEGTQYSSHP	CBL_PTK	0.6457
p.P144Q	DO229018	LICA	ICGC	NPEGTQYSSHP	CBL_PTK	0.5924
p.P160Q	DO229031	LICA	ICGC	NPEGTQYSSHP	CBL_PTK	0.1389
p.Q163K	DO229035	LICA	ICGC	NPEGTQYSSHP	CBL_PTK	0.0556
p.R159G	SIDM00212	Glioblastoma	GDSC	NPEGTQYSSHP	CBL_PTK	0.1667
p.R159G	ACH-000464	Brain Cancer	CCLE	NPEGTQYSSHP	CBL_PTK	0.1667
p.R159G	CAS-1	central_nervous_system	COSMIC	NPEGTQYSSHP	CBL_PTK	0.1667
p.S150N	SIDM00878	Breast Carcinoma	GDSC	NPEGTQYSSHP	CBL_PTK	0.818
p.S150N	ACH-000930	Breast Cancer	CCLE	NPEGTQYSSHP	CBL_PTK	0.818
p.S150N	HCC1569	breast	COSMIC	NPEGTQYSSHP	CBL_PTK	0.818
p.R142G	SIDM00847	Rhabdomyosarcoma	GDSC	NPEGTQYSSHP	CBL_PTK	0.3056
p.R142G	ACH-000169	Sarcoma	CCLE	NPEGTQYSSHP	CBL_PTK	0.3056
p.R142G	RD	soft_tissue	COSMIC	NPEGTQYSSHP	CBL_PTK	0.3056
p.G162D	SIDM00217	Colorectal Carcinoma	GDSC	NPEGTQYSSHP	CBL_PTK	0.0833
p.G162D	SNU-1040	large_intestine	COSMIC	NPEGTQYSSHP	CBL_PTK	0.0833
p.Q148H	SIDM01591	Breast Carcinoma	GDSC	NPEGTQYSSHP	CBL_PTK	0.647
p.Q148H	ACH-000540	Non-Cancerous	CCLE	NPEGTQYSSHP	CBL_PTK	0.647
p.R161M	SIDM01574	Plasma Cell Myeloma	GDSC	NPEGTQYSSHP	CBL_PTK	0.1111
p.R161M	ACH-000588	Myeloma	CCLE	NPEGTQYSSHP	CBL_PTK	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NPEGTQYSSHP

Degron related mutations and impact score

Drug responses associated with TOX mutations

All proteins holding degron of NPEGTQYSSHP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94900	Thymocyte selection-associated high mobility group box protein TOX	CBL_PTK	143:153	NPEGTQYSSHP	CBL	0.889	More...