DegronMD

Uniprot ID: Q9H2P0

Source protein: Activity-dependent neuroprotector homeobox protein

Source gene: ADNP

Class: DEG_ODPH_VHL_1

Location: 271:283

E3 ligase: VHL

DEGRON score: 0.9114

ASA_SCORE: 88.6385

COIL: 0.8917

CONS_SCORE: 0.7394

DSS_SCORE: 0.5694

HELIX: 0.0441

FCONS_SCORE: 1.0036

RIG_SCORE: 0.7012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P267L	TCGA-A5-A0G2	UCEC	TCGA	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	0.2222
p.P267L	DO41235	UCEC	ICGC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	0.2222
p.L270Q	DO23160	LINC	ICGC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	0.3056
p.S292F	SIDM00857	Melanoma	GDSC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	0.5278
p.S292F	ACH-000572	Skin Cancer	CCLE	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	0.5278
p.S292F	G-361	skin	COSMIC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	0.5278
p.P275L	SIDM00445	Esophageal Carcinoma	GDSC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	0.6471
p.P275L	ACH-002292	Esophageal Cancer	CCLE	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	0.6471
p.P275L	OACp4C	oesophagus	COSMIC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2P0	Activity-dependent neuroprotector homeobox protein	DEG_ODPH_VHL_1	271:283	IAPKPQDKKSMGL	VHL	0.9114	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons