DegronMD - Q9H2P0(ADNP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R705W	TCGA-A5-A0G2	UCEC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1389
p.R705W	TCGA-BG-A220	UCEC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1389
p.R705W	DO41784	UCEC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1389
p.R705W	DO41235	UCEC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1389
p.P267L	TCGA-A5-A0G2	UCEC	TCGA	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	271:283	Mutation rewiring degron network	0.2222
p.P267L	DO41235	UCEC	ICGC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	271:283	Mutation rewiring degron network	0.2222
p.L732F	TCGA-A5-A0GA	UCEC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.L732F	DO43763	UCEC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1111
p.K716Q	TCGA-AB-2890	LAML	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.5833
p.K716Q	DO21517	LAML	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.5833
p.D734N	TCGA-AC-A23H	BRCA	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.0556
p.D734N	DO2401	BRCA	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.0556
p.P714H	TCGA-B5-A3FC	UCEC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7694
p.P714H	DO41871	UCEC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7694
p.P710A	TCGA-BR-6454	STAD	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.2778
p.P710A	DO38595	STAD	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.2778
p.R730L	TCGA-EK-A2H0	CESC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1667
p.R730L	DO49020	CESC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1667
p.R705Q	DO233855	GACA	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.1389
p.P703H	DO228948	LICA	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.0833
p.L270Q	DO23160	LINC	ICGC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	271:283	Mutation rewiring degron network	0.3056
p.P703S	DO234122	THCA	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.0833
p.R717H	SIDM02035	Colorectal Carcinoma	GDSC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7133
p.S292F	SIDM00857	Melanoma	GDSC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	271:283	Mutation blocking phosphorylation signal	0.5278
p.S292F	ACH-000572	Skin Cancer	CCLE	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	271:283	Mutation blocking phosphorylation signal	0.5278
p.S292F	G-361	skin	COSMIC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	271:283	Mutation blocking phosphorylation signal	0.5278
p.P275L	SIDM00445	Esophageal Carcinoma	GDSC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	271:283	Mutation altering degron motif	0.6471
p.P275L	ACH-002292	Esophageal Cancer	CCLE	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	271:283	Mutation altering degron motif	0.6471
p.P275L	OACp4C	oesophagus	COSMIC	IAPKPQDKKSMGL	DEG_ODPH_VHL_1	271:283	Mutation altering degron motif	0.6471
p.P725S	SIDM00516	Melanoma	GDSC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.3056
p.P725S	ACH-002166	Skin Cancer	CCLE	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.3056
p.P725S	MZ7-mel	skin	COSMIC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.3056
p.T714A	NTERA-2_cl_D1	testis	COSMIC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7139
p.V734D	HuP-T3	pancreas	COSMIC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation rewiring degron network	0.0556
p.L720P	DB	haematopoietic and lymphoid tissue	COSMIC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	712:724	Mutation altering degron motif	0.7582

Kaplan plot for ADNP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADNP

UniProt ID: Q9H2P0

Entrez ID: 23394

Protein name: Activity-dependent neuroprotector homeobox protein (Activity-dependent neuroprotective protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADNP in