DegronMD

Uniprot ID: Q9H2P0

Source protein: Activity-dependent neuroprotector homeobox protein

Source gene: ADNP

Class: DEG_ODPH_VHL_1

Location: 712:724

E3 ligase: VHL

DEGRON score: 0.7182

ASA_SCORE: 94.3308

COIL: 0.6039

CONS_SCORE: 0.6334

DSS_SCORE: 0.5395

HELIX: 0.3367

FCONS_SCORE: 0.9712

RIG_SCORE: 0.7424

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R705W	TCGA-A5-A0G2	UCEC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.1389
p.R705W	TCGA-BG-A220	UCEC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.1389
p.R705W	DO41784	UCEC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.1389
p.R705W	DO41235	UCEC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.1389
p.L732F	TCGA-A5-A0GA	UCEC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.1111
p.L732F	DO43763	UCEC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.1111
p.K716Q	TCGA-AB-2890	LAML	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.5833
p.K716Q	DO21517	LAML	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.5833
p.D734N	TCGA-AC-A23H	BRCA	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.0556
p.D734N	DO2401	BRCA	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.0556
p.P714H	TCGA-B5-A3FC	UCEC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.7694
p.P714H	DO41871	UCEC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.7694
p.P710A	TCGA-BR-6454	STAD	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.2778
p.P710A	DO38595	STAD	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.2778
p.R730L	TCGA-EK-A2H0	CESC	TCGA	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.1667
p.R730L	DO49020	CESC	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.1667
p.R705Q	DO233855	GACA	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.1389
p.P703H	DO228948	LICA	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.0833
p.P703S	DO234122	THCA	ICGC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.0833
p.R717H	SIDM02035	Colorectal Carcinoma	GDSC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.7133
p.P725S	SIDM00516	Melanoma	GDSC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.3056
p.P725S	ACH-002166	Skin Cancer	CCLE	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.3056
p.P725S	MZ7-mel	skin	COSMIC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.3056
p.T714A	NTERA-2_cl_D1	testis	COSMIC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.7139
p.V734D	HuP-T3	pancreas	COSMIC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.0556
p.L720P	DB	haematopoietic_and_lymphoid_tissue	COSMIC	LAPVKRTYEQMEF	DEG_ODPH_VHL_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2P0	Activity-dependent neuroprotector homeobox protein	DEG_ODPH_VHL_1	712:724	LAPVKRTYEQMEF	VHL	0.7182	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPVKRTYEQMEF

Degron related mutations and impact score

Drug responses associated with ADNP mutations

All proteins holding degron of LAPVKRTYEQMEF