DegronMD

Uniprot ID: Q8NFB2

Source protein: Transmembrane protein 185A

Source gene: TMEM185A

Class: DEG_ODPH_VHL_1

Location: 318:330

E3 ligase: VHL

DEGRON score: 0.7195

ASA_SCORE: 95.8

COIL: 0.5631

CONS_SCORE: 0.3803

DSS_SCORE: 0.4665

HELIX: 0.2689

FCONS_SCORE: 0.9778

RIG_SCORE: 0.7719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T331A	DO52370	LUSC	ICGC	IAPMFRKKARVVI	DEG_ODPH_VHL_1	0.75
p.R323Q	SIDM01942	Colorectal Carcinoma	GDSC	IAPMFRKKARVVI	DEG_ODPH_VHL_1	0.6218
p.G335R	SIDM00007	Other Solid Cancers	GDSC	IAPMFRKKARVVI	DEG_ODPH_VHL_1	0.1944
p.I318F	SIDM00541	Colorectal Carcinoma	GDSC	IAPMFRKKARVVI	DEG_ODPH_VHL_1	0.7415

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFB2	Transmembrane protein 185A	DEG_ODPH_VHL_1	318:330	IAPMFRKKARVVI	VHL	0.7195	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons