DegronMD

Uniprot ID: Q75N03

Source protein: E3 ubiquitin-protein ligase Hakai

Source gene: CBLL1

Class: DEG_ODPH_VHL_1

Location: 209:222

E3 ligase: VHL

DEGRON score: 0.9982

ASA_SCORE: 103.5143

COIL: 0.9392

CONS_SCORE: 0.4356

DSS_SCORE: 0.6576

HELIX: 0.0329

FCONS_SCORE: 1.1228

RIG_SCORE: 0.6448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H228R	TCGA-22-4613	LUSC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.1667
p.R219C	TCGA-2W-A8YY	CESC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.719
p.R219C	TCGA-A5-A0G1	UCEC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.719
p.P213L	TCGA-55-7724	LUAD	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.6471
p.M229I	TCGA-98-8021	LUSC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.1389
p.P223S	TCGA-DK-A6AW	BLCA	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.3056
p.E218Q	TCGA-EK-A2PM	CESC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.5633
p.P222S	DO48566	BLCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.6752
p.P207A	DO225215	BRCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.2778
p.P207A	DO227836	BRCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.2778
p.P232S	DO225215	BRCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.0556
p.P232S	DO227836	BRCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.0556
p.E217Q	DO49941	CESC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.6744
p.R218C	DO223732	CESC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.8301
p.R218C	DO42472	UCEC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.8301
p.P212L	DO45373	LUAD	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.6471
p.H227R	DO26468	LUSC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.1944
p.M228I	DO27468	LUSC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.1667
p.H227Q	SIDM00662	Melanoma	GDSC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.1944
p.H227Q	ACH-000135	Non-Cancerous	CCLE	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.1944
p.H227Q	Hs940-T	skin	COSMIC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.1944
p.H226Q	Hs940-T	skin	COSMIC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q75N03	E3 ubiquitin-protein ligase Hakai	DEG_ODPH_VHL_1	209:222	IAPPPTEIPERFIM	VHL	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons