DegronMD - Q75N03(CBLL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H228R	TCGA-22-4613	LUSC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.1667
p.R219C	TCGA-2W-A8YY	CESC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation altering degron motif	0.719
p.R219C	TCGA-A5-A0G1	UCEC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation altering degron motif	0.719
p.P213L	TCGA-55-7724	LUAD	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation altering degron motif	0.6471
p.M229I	TCGA-98-8021	LUSC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.1389
p.M191V	TCGA-AX-A063	UCEC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1389
p.E203K	TCGA-CV-7095	HNSC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.591
p.R189C	TCGA-D1-A17U	UCEC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0833
p.P223S	TCGA-DK-A6AW	BLCA	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.3056
p.N204S	TCGA-DU-A5TP	LGG	TCGA	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.5958
p.R189H	TCGA-EA-A410	CESC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0833
p.E218Q	TCGA-EK-A2PM	CESC	TCGA	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation altering degron motif	0.5633
p.P196T	TCGA-EO-A22U	UCEC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778
p.R199H	TCGA-ZN-A9VO	MESO	TCGA	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.8244
p.P222S	DO48566	BLCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation altering degron motif	0.6752
p.P207A	DO225215	BRCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.P207A	DO225215	BRCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.2778
p.P207A	DO227836	BRCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.3056
p.P207A	DO227836	BRCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.2778
p.P232S	DO225215	BRCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.0556
p.P232S	DO227836	BRCA	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.0556
p.E217Q	DO49941	CESC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation altering degron motif	0.6744
p.R188H	DO49929	CESC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0556
p.R218C	DO223732	CESC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation altering degron motif	0.8301
p.R218C	DO42472	UCEC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation altering degron motif	0.8301
p.M190T	DO228935	COCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1111
p.R188C	DO222762	COCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0556
p.R188C	DO41887	UCEC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.0556
p.V196I	DO223016	ESCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.2778
p.E202K	DO14252	HNSC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.7022
p.N203S	DO44562	LGG	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.7069
p.N203S	DO231827	LINC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation altering degron motif	0.7069
p.P212L	DO45373	LUAD	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation altering degron motif	0.6471
p.H227R	DO26468	LUSC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.1944
p.M228I	DO27468	LUSC	ICGC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.1667
p.A192T	DO232224	PBCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1667
p.M190V	DO42201	UCEC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation rewiring degron network	0.1111
p.P195T	DO43755	UCEC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	198:206	Mutation substituting flanking lysine	0.3611
p.H227Q	SIDM00662	Melanoma	GDSC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.1944
p.H227Q	ACH-000135	Non-Cancerous	CCLE	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.1944
p.H227Q	Hs940-T	skin	COSMIC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation rewiring degron network	0.1944
p.H226Q	Hs940-T	skin	COSMIC	IAPPPTEIPERFIM	DEG_ODPH_VHL_1	209:222	Mutation substituting flanking lysine	0.3333

Kaplan plot for CBLL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CBLL1

UniProt ID: Q75N03

Entrez ID: 79872

Protein name: E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CBLL1 in