DegronMD

Uniprot ID: Q75N03

Source protein: E3 ubiquitin-protein ligase Hakai

Source gene: CBLL1

Class: DEG_APCC_DBOX_1

Location: 198:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9938

ASA_SCORE: 112.0111

COIL: 0.9192

CONS_SCORE: 0.3601

DSS_SCORE: 0.6234

HELIX: 0.0472

FCONS_SCORE: 0.7172

RIG_SCORE: 0.6348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M191V	TCGA-AX-A063	UCEC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	0.1389
p.E203K	TCGA-CV-7095	HNSC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	0.591
p.R189C	TCGA-D1-A17U	UCEC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	0.0833
p.N204S	TCGA-DU-A5TP	LGG	TCGA	TRASLENVH	DEG_APCC_DBOX_1	0.5958
p.R189H	TCGA-EA-A410	CESC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	0.0833
p.P196T	TCGA-EO-A22U	UCEC	TCGA	TRASLENVH	DEG_APCC_DBOX_1	0.2778
p.R199H	TCGA-ZN-A9VO	MESO	TCGA	TRASLENVH	DEG_APCC_DBOX_1	0.8244
p.P207A	DO225215	BRCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.3056
p.P207A	DO227836	BRCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.3056
p.R188H	DO49929	CESC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.0556
p.M190T	DO228935	COCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.1111
p.R188C	DO222762	COCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.0556
p.R188C	DO41887	UCEC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.0556
p.V196I	DO223016	ESCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.2778
p.E202K	DO14252	HNSC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.7022
p.N203S	DO44562	LGG	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.7069
p.N203S	DO231827	LINC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.7069
p.A192T	DO232224	PBCA	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.1667
p.M190V	DO42201	UCEC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.1111
p.P195T	DO43755	UCEC	ICGC	TRASLENVH	DEG_APCC_DBOX_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q75N03	E3 ubiquitin-protein ligase Hakai	DEG_APCC_DBOX_1	198:206	TRASLENVH	APC,CDC20,FZR1	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons