DegronMD

Uniprot ID: O75369

Source protein: Filamin-B

Source gene: FLNB

Class: DEG_ODPH_VHL_1

Location: 2281:2292

E3 ligase: VHL

DEGRON score: 0.9253

ASA_SCORE: 62.9667

COIL: 0.5294

CONS_SCORE: 0.4314

DSS_SCORE: 0.3154

HELIX: 0.0568

FCONS_SCORE: 0.7781

RIG_SCORE: 0.794

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2280C	TCGA-86-7713	LUAD	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.3056
p.S2282Y	TCGA-AP-A059	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.712
p.K2275T	TCGA-AX-A05Z	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.1667
p.E2292K	TCGA-D3-A8GI	SKCM	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.7022
p.I2284V	TCGA-DF-A2KN	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.7076
p.D2272N	TCGA-EO-A22R	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.0833
p.D2272N	SIDM01199	Hepatocellular Carcinoma	GDSC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.0833
p.D2272N	ACH-000493	Liver Cancer	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.0833
p.D2272N	SNU-423	liver	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.0833
p.P2288S	TCGA-FI-A2D5	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.6752
p.E2296A	DO12424	GBM	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.2222
p.E2291K	DO14654	HNSC	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.7022
p.E2298D	DO228978	LICA	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.6111
p.E2298K	DO220891	MELA	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.6111
p.S2284G	DO51766	STAD	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.5882
p.V2294M	DO52409	UCEC	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.7222
p.A2274T	DO43891	UCEC	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.5833
p.N2290K	SIDM00789	Colorectal Carcinoma	GDSC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.6918
p.N2290K	ACH-000997	Colon/Colorectal Cancer	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.6918
p.N2290K	HCT-15	large_intestine	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.6918
p.V2281L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.6765
p.V2281L	ACH-000945	Lung Cancer	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.6765
p.V2281L	NCI-H650	lung	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.6765
p.S2278W	SIDM01768	Melanoma	GDSC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.25
p.S2278W	ACH-000899	Skin Cancer	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.25
p.S2278L	ACH-000167	Myeloma	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.25
p.P2279Q	IST-MEL1	skin	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.2778
p.A2282T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.7139
p.R2282C	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.8301
p.A2271T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPSDDARRLTV

Degron related mutations and impact score

Drug responses associated with FLNB mutations

All proteins holding degron of IAPSDDARRLTV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75369	Filamin-B	DEG_ODPH_VHL_1	2281:2292	IAPSDDARRLTV	VHL	0.9253	More...