DegronMD - O75369(FLNB)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1656T	TCGA-05-4410	LUAD	TCGA	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation altering degron motif	0.7139
p.A1656T	TCGA-B5-A3FC	UCEC	TCGA	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation altering degron motif	0.7139
p.R1473H	TCGA-2W-A8YY	CESC	TCGA	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1111
p.R1473H	TCGA-AX-A1CE	UCEC	TCGA	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1111
p.R1473H	TCGA-D1-A103	UCEC	TCGA	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1111
p.R1473H	TCGA-L5-A8NM	ESCA	TCGA	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1111
p.R1473H	DO223732	CESC	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1111
p.R1473H	DO42312	UCEC	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1111
p.R1473H	DO42280	UCEC	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1111
p.G2280C	TCGA-86-7713	LUAD	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.3056
p.S2282Y	TCGA-AP-A059	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.712
p.K2275T	TCGA-AX-A05Z	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.1667
p.E2292K	TCGA-D3-A8GI	SKCM	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.7022
p.I2284V	TCGA-DF-A2KN	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.7076
p.E1663K	TCGA-EB-A41A	SKCM	TCGA	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation rewiring degron network	0.1944
p.E1663K	TCGA-EE-A3AA	SKCM	TCGA	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation rewiring degron network	0.1944
p.T1651M	TCGA-EI-6882	READ	TCGA	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation rewiring degron network	0.3056
p.T1651M	DO35110	PACA	ICGC	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation rewiring degron network	0.3056
p.D2272N	TCGA-EO-A22R	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.0833
p.D2272N	SIDM01199	Hepatocellular Carcinoma	GDSC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.0833
p.D2272N	ACH-000493	Liver Cancer	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.0833
p.D2272N	SNU-423	liver	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.0833
p.P2288S	TCGA-FI-A2D5	UCEC	TCGA	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.6752
p.T1661S	TCGA-VQ-A8P3	STAD	TCGA	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation rewiring degron network	0.25
p.K1647E	DO219031	BLCA	ICGC	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation substituting flanking lysine	0.3056
p.V1471M	DO229010	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.0556
p.V1471M	DO229013	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.0556
p.V1471M	DO229016	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.0556
p.V1471M	DO229003	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.0556
p.V1471M	DO229005	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.0556
p.E2296A	DO12424	GBM	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.2222
p.E2291K	DO14654	HNSC	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.7022
p.D1473G	DO228199	LICA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1111
p.E2298D	DO228978	LICA	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation blocking phosphorylation signal	0.6111
p.D1663Y	DO229035	LICA	ICGC	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation rewiring degron network	0.1944
p.N1492S	DO50865	LICA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.2222
p.E2298K	DO220891	MELA	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation blocking phosphorylation signal	0.6111
p.N1474D	DO233298	NACA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1389
p.G1489E	DO47272	SKCM	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.3056
p.G1489D	DO37719	SKCM	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.3056
p.M1492I	DO37406	SKCM	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.2222
p.S1494L	DO37406	SKCM	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.1667
p.S2284G	DO51766	STAD	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.5882
p.V2294M	DO52409	UCEC	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation blocking phosphorylation signal	0.7222
p.A2274T	DO43891	UCEC	ICGC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation blocking phosphorylation signal	0.5833
p.V1481I	DO43714	UCEC	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation altering degron motif	0.5965
p.N2290K	SIDM00789	Colorectal Carcinoma	GDSC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.6918
p.N2290K	ACH-000997	Colon/Colorectal Cancer	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.6918
p.N2290K	HCT-15	large intestine	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.6918
p.V2281L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.6765
p.V2281L	ACH-000945	Lung Cancer	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.6765
p.V2281L	NCI-H650	lung	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.6765
p.S2278W	SIDM01768	Melanoma	GDSC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.25
p.S2278W	ACH-000899	Skin Cancer	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.25
p.S2278L	ACH-000167	Myeloma	CCLE	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.25
p.K1488N	ACH-000698	Lung Cancer	CCLE	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation altering degron motif	0.6918
p.V1483F	NCI-H1694	lung	COSMIC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation altering degron motif	0.7068
p.V1472M	MZ2-MEL	skin	COSMIC	VTYTPSQE	DEG_SCF_FBW7_2	1481:1488	Mutation rewiring degron network	0.0833
p.A1647T	DND-41	haematopoietic and lymphoid tissue	COSMIC	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation substituting flanking lysine	0.3056
p.V1652F	NCI-H1694	lung	COSMIC	VLTPDGT	DEG_SCF_FBW7_1	1652:1658	Mutation altering degron motif	0.7068
p.P2279Q	IST-MEL1	skin	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.2778
p.A2282T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.7139
p.R2282C	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation altering degron motif	0.8301
p.A2271T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	IAPSDDARRLTV	DEG_ODPH_VHL_1	2281:2292	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FLNB

UniProt ID: O75369

Entrez ID: 2317

Protein name: Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FLNB in