DegronMD

Uniprot ID: O75369

Source protein: Filamin-B

Source gene: FLNB

Class: DEG_SCF_FBW7_1

Location: 1652:1658

E3 ligase: FBXW7

DEGRON score: 0.6442

ASA_SCORE: 53.7429

COIL: 0.6874

CONS_SCORE: 0.5088

DSS_SCORE: 0.3512

HELIX: 0.0056

FCONS_SCORE: 1.0529

RIG_SCORE: 0.8174

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1656T	TCGA-05-4410	LUAD	TCGA	VLTPDGT	DEG_SCF_FBW7_1	0.7139
p.A1656T	TCGA-B5-A3FC	UCEC	TCGA	VLTPDGT	DEG_SCF_FBW7_1	0.7139
p.E1663K	TCGA-EB-A41A	SKCM	TCGA	VLTPDGT	DEG_SCF_FBW7_1	0.1944
p.E1663K	TCGA-EE-A3AA	SKCM	TCGA	VLTPDGT	DEG_SCF_FBW7_1	0.1944
p.T1651M	TCGA-EI-6882	READ	TCGA	VLTPDGT	DEG_SCF_FBW7_1	0.3056
p.T1651M	DO35110	PACA	ICGC	VLTPDGT	DEG_SCF_FBW7_1	0.3056
p.T1661S	TCGA-VQ-A8P3	STAD	TCGA	VLTPDGT	DEG_SCF_FBW7_1	0.25
p.K1647E	DO219031	BLCA	ICGC	VLTPDGT	DEG_SCF_FBW7_1	0.3056
p.D1663Y	DO229035	LICA	ICGC	VLTPDGT	DEG_SCF_FBW7_1	0.1944
p.A1647T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VLTPDGT	DEG_SCF_FBW7_1	0.3056
p.V1652F	NCI-H1694	lung	COSMIC	VLTPDGT	DEG_SCF_FBW7_1	0.7068

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75369	Filamin-B	DEG_SCF_FBW7_1	1652:1658	VLTPDGT	FBXW7	0.6442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons