DegronMD

Uniprot ID: O75369

Source protein: Filamin-B

Source gene: FLNB

Class: DEG_SCF_FBW7_2

Location: 1481:1488

E3 ligase: FBXW7

DEGRON score: 0.6229

ASA_SCORE: 51.5625

COIL: 0.4744

CONS_SCORE: 0.586

DSS_SCORE: 0.5066

HELIX: 0.0011

FCONS_SCORE: 1.1374

RIG_SCORE: 0.7493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1473H	TCGA-2W-A8YY	CESC	TCGA	VTYTPSQE	DEG_SCF_FBW7_2	0.1111
p.R1473H	TCGA-AX-A1CE	UCEC	TCGA	VTYTPSQE	DEG_SCF_FBW7_2	0.1111
p.R1473H	TCGA-D1-A103	UCEC	TCGA	VTYTPSQE	DEG_SCF_FBW7_2	0.1111
p.R1473H	TCGA-L5-A8NM	ESCA	TCGA	VTYTPSQE	DEG_SCF_FBW7_2	0.1111
p.R1473H	DO223732	CESC	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.1111
p.R1473H	DO42312	UCEC	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.1111
p.R1473H	DO42280	UCEC	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.1111
p.V1471M	DO229010	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.0556
p.V1471M	DO229013	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.0556
p.V1471M	DO229016	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.0556
p.V1471M	DO229003	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.0556
p.V1471M	DO229005	COCA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.0556
p.D1473G	DO228199	LICA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.1111
p.N1492S	DO50865	LICA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.2222
p.N1474D	DO233298	NACA	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.1389
p.G1489E	DO47272	SKCM	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.3056
p.G1489D	DO37719	SKCM	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.3056
p.M1492I	DO37406	SKCM	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.2222
p.S1494L	DO37406	SKCM	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.1667
p.V1481I	DO43714	UCEC	ICGC	VTYTPSQE	DEG_SCF_FBW7_2	0.5965
p.K1488N	ACH-000698	Lung Cancer	CCLE	VTYTPSQE	DEG_SCF_FBW7_2	0.6918
p.V1483F	NCI-H1694	lung	COSMIC	VTYTPSQE	DEG_SCF_FBW7_2	0.7068
p.V1472M	MZ2-MEL	skin	COSMIC	VTYTPSQE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75369	Filamin-B	DEG_SCF_FBW7_2	1481:1488	VTYTPSQE	FBXW7	0.6229	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons